Exercise on Expression of Heat Shock Protein 70 in Arterial Risk

NCT04743128 | Completed DMC

• 1 other identifier: HSP 70 CLPQ
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: Atherosclerotic Peripheral Arterial Disease (PAD) is the leading cause of mortality in the western world. To maintain homeostasis of the vessel wall, vascular cells produce a high level of heat shock proteins (HSP), among which is Hsp70, to stimulate innate immunity and face stress. Methods: This is a clinical trial where 260 individuals were evaluated by a screening test employing the Ankle-Arm Index (ABI), 220 of them were not within risk value (0.91 to 0.99 mmHg). In the clinical trial, 32 individuals were included. A control group and an experimental group were formed. Aerobic exercise intervention was performed for 12 weeks. The level of Hsp70 was evaluated, physical and clinical measurements were applied at the beginning and at the end of the trial.

Conditions

Peripheral Arterial Disease

Keywords

Peripheral Arterial Disease; Aerobic Exercise; HSP70

Outcome Measures

Primary Outcomes (1)

• Impact of exercise on expression of Hsp70 in individuals at risk of peripheral arterial disease

  This is a clinical trial where 260 individuals were evaluated by a screening test employing the Ankle-Arm Index (ABI). A number of 220 individuals were not within risk value (0.91 to 0.99 mmHg). In the clinical trial, 32 individuals were included. A control group and an experimental group were formed. Aerobic exercise intervention was performed by the experimental group. The level of Hsp70 was evaluated, physical and clinical measurements were applied at the beginning and at the end of the trial.

  12 weeks

Study Arms (2)

Control group

NO INTERVENTION

The control group received written recommendations to exercise three times per week, for a period of 12 weeks but they did not attend the training sessions.

Exercise group

EXPERIMENTAL

The experimental group started an exercise program to achieve 65% to 80% of the maximum heart rate by using a pulsometer that measured the heart rate in order to get to the moderate intensity activity goal. The exercise session was 60 minutes long, three times per week, completing 180 minutes per week of moderate intensity exercise, for 12 weeks in total.

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

The experimental group started an exercise program to achieve 65% to 80% of the maximum heart rate by using a pulsometer that measured the heart rate in order to get to the moderate intensity activity goal. The exercise session was 60 minutes long, three times per week, completing 180 minutes per week of moderate intensity exercise, for 12 weeks in total.

Exercise group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• ABI cut point from 0.91 to 0.99
• Age, from 40 to 75 years old
• Both genders

You may not qualify if:

• Unable to perform Bruce's stress test
• Presence of fractures or sprains in the last 3 months
• Diagnosis of diabetes, heart disease, angina pectoris or heart attack

Sponsors & Collaborators

• Universidad Popular Autónoma del Estado de Puebla: lead

Study Sites (1)

UPAEP

Puebla City, 72410, Mexico

Location

MeSH Terms

Conditions

Peripheral Arterial Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Atherosclerosis; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Peripheral Vascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Clara Luz Pérez Quiroga, MCs

  Universidad Popular Autónoma del Estado de Puebla

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MSc

Study Record Dates

• First Submitted: January 27, 2021
• First Posted: February 8, 2021
• Study Start: June 3, 2019
• Primary Completion: August 30, 2019
• Study Completion: August 30, 2019
• Last Updated: May 4, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)