Failure of a Single Surgical Debridement in Septic Arthritis of the Native Hip

NCT04742127 | Active Not Recruiting

• 1 other identifier: S64930
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Septic arthritis of the native hip poses significant diagnostic and therapeutic challenges as it is considered an orthopedic emergency requiring urgent surgery. Inadequate or delayed treatment is disastrous, resulting in irreversible destruction of the joint. Initial treatment usually comprises of arthroscopic or open debridement. According to literature 25-38% of first debridement fail, requiring a second or third intervention or even a staged procedure with femoral head resection and a temporary antibiotic-loaded cement spacer. Understanding who will succeed and who will fail after a single surgical debridement of a septic hip joint could improve shared decision-making and could help decide which patient would benefit from resection arthroplasty straight away. In order to gain more insight in clinical factors associated with failure of a single surgical debridement in septic arthritis of the native hip, a retrospective cohort study will be conducted. There are no detailed guidelines for the treatment of septic arthritis of the native hip. Therefore, treatment today is similar to treatment 10 years ago (i.e. the treating surgeon does what he thinks is best for the patient). This lack of a structured approach is the reason for this retrospective study and we aim to come up with principles to guide treatment of future patients.

Conditions

Septic Arthritis of the Native Hip; Failure of Initial Debridement

Outcome Measures

Primary Outcomes (1)

• Clinical factors associated with failure of a single surgical debridement

  A retrospective data registry containing clinical data of patients with septic arthritis of the native hip will be constructed. This data registry will contain a sizable amount of clinico-pathological features collected from the electronic patient registry. Subsequently, a retrospective cohort study will be conducted in order to establish associations between certain clinical factors and the likelihood of failure of the initial surgical debridement.

  Through study completion, an average of 1 year

Secondary Outcomes (6)

• Population of patients who would benefit from a staged procedure

  Through study completion, an average of 1 year

• Prevalence of failure of initial debridement

  Through study completion, an average of 1 year

• Prevalence of staged procedure

  Through study completion, an average of 1 year

• Mortality

  Through study completion, an average of 1 year

• Recurrence

  Through study completion, an average of 1 year

Study Arms (1)

Patients with septic arthritis of the native hip

Diagnostic Test: Single surgical debridement

Interventions

Single surgical debridement DIAGNOSTIC_TEST

To describe the clinical factors associated with failure of a single surgical debridement in patients with septic arthritis of the native hip.

Patients with septic arthritis of the native hip

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with septic arthritis of the native hip treated at UZ Leuven in the last decade

You may qualify if:

• All microbiology reports for cases of septic arthritis of the native hip joint concerning synovial fluid or solid tissue cultures obtained from arthrocentesis/debridement of the hip, collected from January 1st 2010 to January 1st 2020
• Patients are at least 18 years of age
• Cases with positive cultures in patients of which the initial diagnosis, treatment and follow-up was conducted at UZ Leuven Gasthuisberg

You may not qualify if:

• \- History of arthroplasty of the hip in the affected joint

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

UZ Leuven

Leuven, 3000, Belgium

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 29, 2021
• First Posted: February 5, 2021
• Study Start: January 26, 2021
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: July 3, 2024

Record last verified: 2024-07

Locations

BE (1)