PAtterns and Extension in COVID-19 Related Interstitial Pneumonia: CT Analysis

NCT04741178 | Unknown

• 1 other identifier: Paesi-COV-19
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The hallmark of the L phenotype is the vasoplegia, as confirmed by the rapid change in density and distribution of CT findings from the supine to the prone position. The benefit of a prone position in awake, nonintubated, spontaneously breathing Covid-19 patients has been emerging as potential tool to improve oxygenation and to prevent the access to ICU. No evidence of radiological modifications related to Aim of our study is to evaluate CT changes in terms of extension, distribution and prevalence of findings, in the supine compared with the prone position.

Conditions

Covid19

Outcome Measures

Primary Outcomes (1)

• CT evidence of peculiar patterns in Covid-19 pneumonia

  Identification of CT findings in order to define peculiar pattern of Covid-19 pneumonia

  March 2020-January 2021

Study Arms (1)

Patient with Covid-pneumonia

Patient with CT scan of pulmonary infiltrates suggestive of Covid pneumonia

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients were considered eligible if were with a confirmed diagnosis of Covid-19 infection, as documented by RT-PCR nasal swab, or, confirmed by a subsequent BAL, aged between 18 and 90 years old, able to maintain both the supine and prone position on the CT scan table. Patients who were pregnant, scarcely collaborative were excluded. CT analysis was conducted by two experienced thoracic radiologists and one pulmonologist. Extension of each CT finding and presence of vessel enlargement has been scored.

You may qualify if:

• Confirmed diagnosis of Covid-19 infection, as documented by RT-PCR nasal swab, or, confirmed by a subsequent BAL
• Age between 18 and 90 years old
• Ability to maintain both the supine and prone position on the CT scan table.

You may not qualify if:

• Patients who were pregnant, scarcely collaborative

Sponsors & Collaborators

• Morgagni Pierantoni Hospital: lead

Study Sites (1)

Morgagni Pierantoni Hospital

Forlì, FC, 47121, Italy

RECRUITING

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 3, 2021
• First Posted: February 5, 2021
• Study Start: March 20, 2020
• Primary Completion: January 2, 2021
• Study Completion: December 31, 2021
• Last Updated: February 10, 2021

Record last verified: 2021-02

Locations

IT (1)