Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia

NCT04739748 | Completed

• 1 other identifier: IRB17300520
• Study Type: observational
• Target: 136
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.

Conditions

Ventilator Associated Pneumonia

Keywords

Red cell distribution width; neutrophil-lymphocyte ratio; Intensive care units; Respiratory

Outcome Measures

Primary Outcomes (1)

• Hospital Mortality

  The number of patients who not Survive after developing ventilator-associated pneumonia in their stay in the Respiratory Intensive Care Unit.

  45 days

Study Arms (1)

Respiratory ICU patient

patient in RICU that developed ventilator-associated pneumonia

Diagnostic Test: complete blood picture

Interventions

complete blood picture DIAGNOSTIC_TEST

Measure the red blood cell distribution width (RDW), the neutrophil-lymphocyte ratio (NLR).

Respiratory ICU patient

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients with the clinical suspicion of VAP in the Respiratory ICU were included in the study.

You may qualify if:

• Respiratory failure needs mechanical ventilator support \> 48 hrs. VAP was defined as an acute lower respiratory tract infection in mechanically ventilated patient \> 48 hrs with a new or progressing infiltrate on chest radiograph and who met at least two of the following clinical criteria: body temperature \>38°C or \<36°C with no other recognized cause, white blood cell count \>10,000 /mm3 or \<5000 /mm3, or a macroscopically purulent tracheal aspirate
• Only the first VAP episode was included

You may not qualify if:

• Neutropenia (\< 500 cells/ml) before the development of VAP.
• Conditions are known to influence total and differential WBC counts such as chronic inflammatory conditions, hematologic disorders, history of chemotherapy, or radiotherapy within 4 weeks before enrollment.
• Conditions are known to affect RDW as anemia due to nutritional deficiency (ie, iron, vitamin B12, and folic acid).
• Patients with HIV/AIDS

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Chest Department-faculty of medicine-Assuit university

Asyut, Egypt

Location

Related Publications (3)

• Huang KT, Tseng CC, Fang WF, Lin MC. An early predictor of the outcome of patients with ventilator-associated pneumonia. Chang Gung Med J. 2010 May-Jun;33(3):274-82.

  PMID: 20584505 RESULT

• Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med. 2002 Apr 1;165(7):867-903. doi: 10.1164/ajrccm.165.7.2105078.

  PMID: 11934711 RESULT

• Bello S, Fandos S, Lasierra AB, Minchole E, Panadero C, Simon AL, Gavin O, De Pablo F, Menendez R, Torres A. Red blood cell distribution width [RDW] and long-term mortality after community-acquired pneumonia. A comparison with proadrenomedullin. Respir Med. 2015 Sep;109(9):1193-206. doi: 10.1016/j.rmed.2015.07.003. Epub 2015 Jul 14.

  PMID: 26205553 RESULT

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated

Condition Hierarchy (Ancestors)

Healthcare-Associated Pneumonia; Cross Infection; Infections; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecture in Faculty of medicine,Assiut University

Study Record Dates

• First Submitted: January 28, 2021
• First Posted: February 5, 2021
• Study Start: April 6, 2018
• Primary Completion: December 7, 2019
• Study Completion: December 7, 2019
• Last Updated: February 8, 2021

Record last verified: 2021-02

Locations

EG (1)