Telegenetics or In-Person Genetic Counselling

NCT04738708 | Recruiting

• 1 other identifier: 002.1
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare clinical outcomes (informed choice and genetic counselling outcomes) and cost (provider and patient time, travel, and telehealth platform) between telegenetics and in-person genetic counselling.

Conditions

Genetic Counselling

Outcome Measures

Primary Outcomes (1)

• Genomics Outcome Scale

  Patient reported outcomes will be compared with a 6 item Genomics Outcome Scale (GOS) across five domains (decisional control, cognitive control, behavioral control, emotional regulation and hope) which are rated on a 5-point Likert scale ranging from "strongly agree" to "strongly disagree". Scores are summed to provide an overall "empowerment" where higher scores equal higher levels of empowerment.

  Up to 2 weeks after consultation

Secondary Outcomes (3)

• Adapted Multidimensional Measure of Informed Choice (MMIC) for Hereditary Breast and Ovarian Cancer (HBOC) and Lynch

  Up to 2 weeks after consultation

• Genetic Counselling Satisfaction Scale

  Up to 2 weeks after consultation

• Telehealth Patient Survey

  Up to 2 weeks after consultation

Study Arms (1)

Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.

Patients attending genetic counselling for Hereditary Breast and Ovarian Cancer (HBOC) and Lynch Syndrome in Clinical Genetic Services (CGS) at National Cancer Centre Singapore (NCCS)

Other: Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.

Interventions

Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling. OTHER

Patients are given a series of questions evaluating cognitive and psychosocial outcomes, either via hardcopy in-person or online internet-facing questionnaire.

Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.

You may qualify if:

• Age ≥ 21 years old.
• Patients referred to CGS at NCCS for HBOC or Lynch syndrome pre-test genetic counselling.
• Able to read and understand the English Language.
• Able to consent and agree to be randomized to either telegenetics or in-person genetic counselling.

You may not qualify if:

• Under the age of 21 years old.
• Patients who require genetic results urgently.
• Cognitive difficulty/ impairment or current psychiatric or physical illness (visual/ hearing/ neurological) which impairs sound judgement and accurate reporting of medical history over video consultation.

Sponsors & Collaborators

• National Cancer Centre, Singapore: lead

Study Sites (1)

National Cancer Centre Singapore

Singapore, 169610, Singapore

RECRUITING

Related Publications (26)

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Study Officials

• Ryan Tan

  National Cancer Centre, Singapore

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ryan Tan

CONTACT

+65 6436 8000; ryan.shea.tan.y.c@singhealth.com.sg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 31, 2021
• First Posted: February 4, 2021
• Study Start: February 1, 2021
• Primary Completion (Estimated): October 6, 2026
• Study Completion (Estimated): October 6, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

SG (1)