Exploring Vaccine Confidence and Uptake of Potential COVID-19 Vaccines

NCT04731870 | Completed

• 1 other identifier: 60622
• Study Type: observational
• Target: 632
• Locations: 1 country
• Sites: 1

Brief Summary

The COVID-19 pandemic has highlighted deleterious US health inequities. Specifically, African Americans, Latinos, and Native Americans have and continue to shoulder a greater burden of COVID-19 infections and deaths in the US. In addition to existing racial and ethnic disparities are rural health and regional disparities. Given the disproportionate impact of disease in US communities of color and also in rural and southern regions of the US, there is no doubt that these at-risk subgroups will continue to experience higher rates of coronavirus-related mortality as well as other long-term health outcomes as compared to other US populations. It is unknown how healthcare providers and other key at-risk subgroups within the US will receive COVID-19 vaccines. For success in immunizations, the US will need to reach their most at-risk and vulnerable populations. In addition to at-risk populations, a successful immunization strategy will involve engaging providers to support clear, consistent, and strong vaccine recommendation. It is critical to build vaccine trust, confidence, and overall acceptance of COVID-19 vaccines among healthcare providers and key at-risk subgroups, especially given the accelerated production timeline of these vaccines. Likewise, tailored vaccine messaging for key subgroups is vital in achieving vaccine confidence and trust. The proposed study will explore perceptions, confidence, trust, and uptake of potential COVID-19 vaccines among healthcare providers (nurses and doctors) and key at-risk population subgroups (minority populations living in the rural south) and will develop and test vaccine messaging that boosts vaccine confidence and trust among these key at-risk subgroups.

Conditions

Coronavirus

Outcome Measures

Primary Outcomes (5)

• Covid-19 vaccine confidence (survey to be developed by study team)

  Confidence in the Covid-19 vaccine efficacy and safety among a cross-section of healthcare providers and key at-risk subgroups in the US

  year 1

• Covid-19 vaccine messaging (messages to be developed by study team & focus group participants)

  COVID-19 vaccine messaging (e.g. one or two sentences of culturally appropriate messages) that can be used to boost vaccine confidence and trust, and COVID-19 preventive behavior, among at-risk subgroups in the US (minority populations living in the rural south).

  year 2

• Covid-19 vaccine uptake (survey to be developed by study team)

  COVID-19 vaccine uptake or projected uptake among a cross-section of healthcare providers and key at-risk subgroups in the US

  year 1

• Covid-19 vaccine trust (survey to be developed by study team)

  COVID-19 vaccine trust in the health system and public health authorities a cross-section of healthcare providers and key at-risk subgroups in the US

  year 1

• Covid-19 vaccine recommendation practices (survey to be developed by study team)

  COVID-19 vaccine recommendation practices among a cross-section of healthcare providers in the US

  year 1

Study Arms (2)

Nurses/Doctors

Covid-19 vaccine confidence and recommendation practices of nurses/doctors

Other: Survey research

Minority populations living in rural south

Covid-19 vaccine confidence and uptake of key at-risk subgroups and tailored Covid-10 vaccine messaging for at-risk subgroups.

Other: Survey research

Interventions

Survey research OTHER

This is not an intervention study. It involves social science research of surveys and focus groups.

Minority populations living in rural south; Nurses/Doctors

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Objectives 1 and 2 will be met by administering an electronic quantitative survey among the following four distinct groups: 1) Nurses (at least 50% from the south), 2) Primary Care/Family Physicians (at least 50% from the south), 3) Rural, low-income, minority men and women living in the south (income of $25K per year or less and 70% of respondents will be Black, Latina, or Native American) and 4) Urban, low-income minority men and women living in the south (income of $25K per year or less and 70% of respondents will be Black, Latina, or Native American). Each group will contain at least 150 subjects for a total of 600 participants.

You may qualify if:

• Nurses (at least 50% from the south),
• Primary Care/Family Physicians (at least 50% from the south),
• Rural, low-income, minority men and women living in the south (income of $25K per year or less and 70% of respondents will be Black, Latina, or Native American) and
• Urban, low-income minority men and women living in the south (income of $25K per year or less and 70% of respondents will be Black, Latina, or Native American).

Sponsors & Collaborators

• East Carolina University: lead

Study Sites (1)

Carol Belk Building

Greenville, North Carolina, 27858, United States

Location

MeSH Terms

Conditions

Coronavirus Infections

Condition Hierarchy (Ancestors)

Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections

Study Officials

• Becky Welch, CPA

  Assistant Vice Chancellor for Research Administration & Finance

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 27, 2021
• First Posted: February 1, 2021
• Study Start: February 28, 2021
• Primary Completion: January 1, 2023
• Study Completion: March 31, 2023
• Last Updated: July 27, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)