The Morphology and Parameter Estimation of Cranial Ultrasound Spectrum Based on Cerebral Artery

NCT04730713 | Unknown

• 1 other identifier: 202101009
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.Observe the changes of TCD/TCCD spectrum shape before and after lumbar puncture in patients with severe neurological disease.
2. 2.Discuss the TCD/TCCD spectrum shape and parameters of cerebral arteries and neurocritical patients Correlation of intracranial pressure.

Conditions

Intracranial Pressure Increase

Keywords

Transcranial Doppler（TCD）,Intracranial pressure(ICP)

Outcome Measures

Primary Outcomes (1)

• The TCD/TCCD spectrum shape and parameters of cerebral arteries are related to the intracranial pressure of neurocritical patients

  The change of TCD/TCCD spectrum shape can qualitatively evaluate ICP. The intracranial pressure is qualitatively determined by spectrum morphology to help clinicians quickly assess intracranial pressure and guide treatment. Accurately identify the normal shape of the spectrum, the state of high resistance, the state of ischemia, the state of congestion, the state of spasticity, the state of nail wave/oscillating wave, and the state of S1S2 fusion high tip. Discuss the correlation between spectrum shape and waist piercing ICP.

  January 26, 2021 to December 30, 2022

Study Arms (1)

Admitted to the center ICU due to neurosurgery, brain dysfunction and other neurological reasons

Aneurysmal subarachnoid hemorrhage (aSAH), traumatic brain injury (TBI), acute deficiency Blood stroke (AIS), acute cerebral hemorrhage (ICH), hypoxic ischemic encephalopathy (HIE), Sepsis-associated encephalopathy (SAE), intracranial tumor surgery; older than 18 years old, \<85 Years old; patients who need lumbar puncture.

Device: The morphology and parameters of cranial ultrasound spectrum based on cerebral artery

Interventions

The morphology and parameters of cranial ultrasound spectrum based on cerebral artery DEVICE

Subjects who meet the standards will undergo a full-body examination and basic life after entering the ICU Sign evaluation and monitoring, mainly including nervous system specialist physical examination, multi-modal brain function testing, Respiratory system monitoring and management, hemodynamic monitoring, APACHE Ⅱ score, GCS score, and routine general circulation, respiratory management, sedation and analgesia management, temperature management, infiltration Pressure management, lumbar pressure measurement The included subjects were monitored for optic nerve sheath diameter, TCD/TCCD before and after lumbar puncture, and recorded spectrum morphology: normal, high resistance state, ischemic topic, congestion state, spasticity, nail wave/oscillating wave state, S1S2 fusion high point state, and recording at the same time Parameters: systolic flow rate (Vs) Shu Tensile blood flow velocity (Vd), average blood flow velocity (Vm), pulsatility index (PI), impedance Index (RI)

Also known as: transcranial Doppler

Admitted to the center ICU due to neurosurgery, brain dysfunction and other neurological reasons

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Age over 18 years old, \<85 Years old; patients who need lumbar puncture.

You may qualify if:

• Aneurysmal subarachnoid hemorrhage (aSAH), traumatic brain injury (TBI), acute deficiency Blood stroke (AIS), acute cerebral hemorrhage (ICH), hypoxic ischemic encephalopathy (HIE), Sepsis-associated encephalopathy (SAE), intracranial tumor surgery; older than 18 years old, \<85 Years old; patients who need lumbar puncture.

You may not qualify if:

• Age \<18 years old;
• Pregnancy;
• The condition of the temporal window is limited and the image cannot be obtained;
• The frequency spectrum of bilateral cerebral arteries shows stenosis;
• Patients with cerebral artery stenosis
• Patients who have not obtained informed consent;

Sponsors & Collaborators

• Xiangya Hospital of Central South University: lead

Study Sites (1)

medical Ethics committee of Xiangya Hospital Central South University

Changsha, Hunan, 410008, China

RECRUITING

MeSH Terms

Conditions

Intracranial Hypertension

Interventions

Ultrasonography, Doppler, Transcranial

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Echoencephalography; Neuroradiography; Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Radiography; Ultrasonography; Ultrasonography, Doppler; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• li na li na, PhD Tutor

  Department of Critical Care Medicine, Central South University

  STUDY CHAIR

Central Study Contacts

li na Zhang, PhD Tutor

CONTACT

86-15874875763; zln7095@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 25, 2021
• First Posted: January 29, 2021
• Study Start: January 26, 2021
• Primary Completion: December 30, 2022
• Study Completion: December 30, 2022
• Last Updated: February 2, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)