Epileptogenic Focus Localization for Children With Epilepsy Using 18F-FDG PET Molecular Imaging
1 other identifier
observational
234
1 country
1
Brief Summary
This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with epilepsy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2014
CompletedFirst Submitted
Initial submission to the registry
January 25, 2021
CompletedFirst Posted
Study publicly available on registry
January 26, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedJuly 12, 2021
July 1, 2021
7 years
January 25, 2021
July 6, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Accuracy
The accuracy of epilepsy focus localization.
Through study completion, about 6 months
Kappa
The agreement between experiment result and clinical diagnosis.
Through study completion, about 6 months
Study Arms (3)
Epilepsy patients
Pediatric patients with focal epilepsy.
Control
Age-matched controls who underwent 18F-FDG PET/CT examination for diseases outside brains.
Validation
Children who underwent 18F-FDG PET/MRI to examine extracranial tumors.
Interventions
Eligibility Criteria
130 pediatric patients with focal epilepsy, 67 age-matched controls, and 37 validation group children.
You may qualify if:
- \. age between 6 and 18 years.
- \. detailed presurgical evaluation, including seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/Computer Tomography (CT) examination.
- \. clinical diagnosis as focal epilepsy.
You may not qualify if:
- \. any history of central nervous system (CNS) disease such as trauma and CNS tumor.
- \. poor image quality due to head movement.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
Related Publications (1)
Zhang T, Li Y, Zhao S, Xu Y, Zhang X, Wu S, Dou X, Yu C, Feng J, Ding Y, Zhu J, Chen Z, Zhang H, Tian M. High-resolution pediatric age-specific 18F-FDG PET template: a pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1560-1573. doi: 10.1007/s00259-021-05611-w. Epub 2021 Nov 8.
PMID: 34746970DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 25, 2021
First Posted
January 26, 2021
Study Start
July 1, 2014
Primary Completion
June 30, 2021
Study Completion
June 30, 2021
Last Updated
July 12, 2021
Record last verified: 2021-07