Fluid Intake After Hemodialysis

NCT04721652 | Recruiting

• 1 other identifier: 117983
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

Interdialytic weight gain determines how much fluid (ultrafiltration) has to be removed during each hemodialysis session. High ultrafiltration volumes stress the organism and lead to a higher risk of death. Thirst is the main driving factor of interdialytic weight gain, and thirst is mainly driven by salt intake, molecules that increase blood tonicity (such as sugar in diabetics) and fluid loss (such as in dehydration and blood loss). It has been speculated that fluid loss during hemodialysis could increase the sense of thirst immediately following dialysis, but this statement requires further evidence.

Conditions

Interdialytic Weight Gain; Chronic Kidney Disease Requiring Chronic Dialysis

Keywords

Hemodialysis; Interdialytic Weight Gain; Thirst

Outcome Measures

Primary Outcomes (2)

• T50%IDWG

  Time to achieve ≥50% cumulative interdialytic weight gain (T50%IDWG) from the last hemodialysis treatment

  Up to one week

• Cumulative IDWG% curve

  Shape of cumulative interdialytic weight gain curve (linear vs nonlinear)

  Up to one week

Secondary Outcomes (4)

• Correlations of T50%IDWG

  One week, Interdialytic intervals

• Correlations of Nighttime cumulative %IDWG

  One week, Interdialytic intervals

• Comparisons between IDWG% curves

  One week, Interdialytic intervals

• Daytime vs Nighttime cumulative IDWG%

  One week, Interdialytic intervals

Study Arms (1)

Hemodialysis Patients (nondiabetic)

Nondiabetic adult hemodialysis patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

In this observational study, we will have a sample of approximately 20 patients on chronic thrice weekly HD self-monitor their weight gain and blood pressure during the interdialytic intervals for one week. Demographics, anthropometrics, HD prescription and treatment information will be recorded. Study participants will complete four questionnaires at the first study visit and will then be provided medical grade scales and a blood pressure monitor, and will be asked to prospectively record weight changes and blood pressure at home four times a day for one week using a logbook. Patients with significant residual urinary volume and diabetes mellitus will not be recruited, the latter to remove the bias of blood glucose in determining osmotic thirst.

You may qualify if:

• Age ≥ 18 years
• Thrice weekly maintenance hemodialysis
• Willing and able to provide written informed consent

You may not qualify if:

• Diabetes Mellitus
• Residual Urinary Volume \> 500 ml/day
• Being able to self-monitor one's body weight and blood pressure

Sponsors & Collaborators

• London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's: lead

Study Sites (2)

Adam Linton Unit

London, Ontario, N6A 5W9, Canada

RECRUITING

Westmount Kidney Care Centre

London, Ontario, N6K 1M6, Canada

RECRUITING

Study Officials

• Christopher W. McIntyre, MD, PhD

  London Health Sciences Centre, Western University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christopher W. McIntyre, MD, PhD

CONTACT

+1(519)685-8500; cmcint48@uwo.ca

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Director of The Lilibeth Caberto Kidney Clinical Research Unit

Study Record Dates

• First Submitted: January 13, 2021
• First Posted: January 25, 2021
• Study Start: February 25, 2021
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)