LUNA-EMG to Enhance Motor Functions in Multiple Sclerosis
LUNA-MS
LUNA-EMG to Enhance Lower Limb Motor Functions in Multiple Sclerosis
1 other identifier
interventional
42
1 country
1
Brief Summary
The aim of the present study is to evaluate the effects of training performed with the LUNA-EMG system to enhance motor functions of the lower limb in multiple sclerosis. This is a randomized open-label trial. Patients will be randomized into the intervention group (LUNA-EMG, 30-45 minutes once a week for 12 weeks) or in the control group (standard care). The effect of the training will be measured based on the muscular strength, walking tests, proprioception and a quality of life questionnaire.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable multiple-sclerosis
Started Mar 2021
Longer than P75 for not_applicable multiple-sclerosis
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 19, 2021
CompletedFirst Posted
Study publicly available on registry
January 22, 2021
CompletedStudy Start
First participant enrolled
March 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2024
CompletedAugust 5, 2025
July 1, 2025
3.3 years
January 19, 2021
July 30, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Muscle strength in mV
Muscular strength is measured with a dynamometer.
12 weeks
Secondary Outcomes (3)
Timed 25-Foot Walk, seconds
12 weeks
Timed Up and Go, seconds
12 weeks
Proprioception
12 weeks
Study Arms (2)
LUNA-EMG
EXPERIMENTALThe experimental group will receive 30 minutes of training with the LUNA-EMG once a week for 12 weeks.
Control
NO INTERVENTIONThe control group will receive its rehabilitation care.
Interventions
The LUNA-EMG (Samcom) system is a robot that allows the evaluation of muscular strength through the recording of muscle activity (electromyography - EMG) in order to provide precise objective data on the patient's muscle function. In addition to the diagnostic aspect (evaluation of muscle strength, range of motion and proprioception), the LUNA-EMG robot provides optimized range of motion's movements and a visual feedback on the patient's performance. In addition, it may enhance neuroplasticity due to the increased number of movements repetitions which could influence motor learning.
Eligibility Criteria
You may qualify if:
- EDSS less or equal to 6.5
- Between 18 and 70 years old
- Having signed the informed consent
You may not qualify if:
- Acute pain syndrome
- Severe cognitive deficits
- Risk of fracture or unconsolidated fracture
- Rigid joints (spasticity, severe osteoarthritis and arthritis) or unstable joints
- Severe ataxia and apraxia
- Epilepsy
- Pacemakers and similar implants
- Insufficient skin conditions
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CNRF
Tinlot, Liege, 4557, Belgium
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
January 19, 2021
First Posted
January 22, 2021
Study Start
March 1, 2021
Primary Completion
June 1, 2024
Study Completion
June 1, 2024
Last Updated
August 5, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will not share