PrEP Awareness, Barriers and Facilitators for PrEP Uptake, and Dosing Mechanisms on Willingness to Take PrEP Among MSM

NCT04719364 | Unknown

• 1 other identifier: 480121
• Study Type: observational
• Target: 330
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are conducting a one and one-half year mixed-methods study to evaluate self-reported sexual risk, knowledge and barriers/facilitators of PrEP use, and preferences of oral, injectable, and implantable PrEP treatment modalities-as a function of race and age, and experience with intersectional discrimination. The first qualitative phase of our study would be conducted over the first eight months, followed by a quantitative phase that will collect data via online cross-sectional survey over the remaining ten months.

Conditions

PrEP; Discrimination, Racial; Stigma, Social

Keywords

PrEP; MSM; Barriers; Facilitators; Discrimination

Outcome Measures

Primary Outcomes (11)

• condomless anal intercourse

  frequency of condomless intercourse with other men

  Baseline

• Awareness of PrEP

  Survey item adapted from the NHBS-- yes/no

  Baseline

• Likelihood of daily PrEP use

  5-point Likert scale measuring likelihood of using daily oral PrEP if freely available and covered by insurance

  Baseline

• Barriers to PrEP use

  6-item checklist of barriers as previously reported in peer-reviewed literature and confirmed by proposed qualitative research

  Baseline

• Facilitators of PrEP use

  7-item checklist of facilitators as previously reported in peer-reviewed literature and confirmed by proposed qualitative research

  Baseline

• Injectable PrEP treatment modality preference

  5- item Likert scale to report likelihood of using monthly injectable PrEP versus daily oral dosing

  Baseline

• Implantable PrEP treatment modality preference

  5- item Likert scale to report likelihood of using long-acting implantable PrEP versus daily oral dosing

  Baseline

• Long-acting oral PrEP treatment modality preference

  5- item Likert scale to report likelihood of using long-acting oral PrEP versus daily oral dosing

  Baseline

• Intersectional anticipated discrimination scale

  5-point Likert scale to measure likelihood of anticipated experiences with discrimination (subscale from Scheim and Bauer,2019; Intersectional Discrimination Index: 0-4 score for each of 11 items which are then averaged for a score of 0-4; higher mean score associated with greater risk of high risk sexual outcome as well as preference for long-acting PrEP treatment modalities that required less interaction with healthcare system)

  Baseline

• Intersectional day-to-day discrimination index

  4-point frequency scale to measure occurrence of day-to-day experiences with discrimination (subscale from Scheim and Bauer ,2019; Intersectional Discrimination Index: 0-2 score for each of 9 items for a range of values between 0-18; higher score associated with greater risk of high risk sexual outcome as well as preference for long-acting PrEP treatment modalities that required less interaction with healthcare system)

  Baseline

• Intersectional major discrimination index

  3-frequency scale for major experiences due to discrimination (subscale from Scheim and Bauer, 2019) Intersectional Discrimination Index: 0-2 score for each of 13 items which are then summed for scores of 0-26 (lifetime experience); higher scores associated with greater risk of high risk sexual outcome as well as preference for long-acting PrEP treatment modalities that required less interaction with healthcare system)

  Baseline

Study Arms (2)

Focus Groups

10 black, 10 Latinx, and 10 white MSM will be recuited in this focus group 'cohort'

Quantitative Survey Group

Cross-sectional group of 100 black, 100 Latinx, and 100 white MSM

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: cis Male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The proposed mixed methods study will evaluate PrEP awareness, barriers and facilitators of uptake, and preference for monthly injectable and annual implantable PrEP versus daily oral medication in a diverse racial/ethnic sample of men who have sex with men (MSM). Specifically, we plan to recruit sufficient numbers (n=300 total) of black MSM (n=100) and Hispanic/Latino MSM (n=100), as well as non-Hispanic/Latino White men (n=100) (at least 18 years of age) to enable our team to evaluate disparities concerning PrEP awareness and knowledge, as well as potential preferences for specific treatment modalities.

You may qualify if:

• Self-identifying as gay, bisexual or a man who has sex with men (MSM)
• Being at least 18 years of age; 3) self-reporting as being HIV-negative
• Having had anal intercourse with a man in the past six months
• Not in a monogamous partnership with a recently tested, HIV-negative man AND at least one of the following: Any anal sex without condoms (receptive or insertive) in past 6 months or having been diagnosed with a bacterial STI (syphilis, gonorrhea, or chlamydia) in past 6 months.

You may not qualify if:

• None

Sponsors & Collaborators

• Drexel University: lead
• Temple University: collaborator

Study Sites (1)

Drexel Dornsife School of Public Health

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

MeSH Terms

Conditions

Racism; Social Stigma

Condition Hierarchy (Ancestors)

Prejudice; Social Behavior; Behavior; Social Discrimination

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Epidemiology

Study Record Dates

• First Submitted: November 9, 2020
• First Posted: January 22, 2021
• Study Start: February 1, 2021
• Primary Completion: April 30, 2022
• Study Completion: April 30, 2022
• Last Updated: January 22, 2021

Record last verified: 2021-01

Locations

US (1)