Thorax MRI for Evaluation of Lung Morphology, Ventilation and Perfusion

NCT04719078 | Unknown

• 1 other identifier: MR 02
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

In spite of the considerable technical difficulties, several publications confirm the potential that T1-maps and MRI to characterize pathological changes in lung tissue. However, existing literature still cannot provide a final evaluation of the presented methods. Study participants won't have any disadvantage in participating the study since all of them undergo next to the MRI-Scan also the two standard methods: CT and lung function test. In this study the value of chest MR compared to CT and LFT in the evaluation of morphological lung changes and their correlation to lung ventilation and perfusion will be evaluated.

Conditions

Lung Diseases; Interstitial Lung Disease

Outcome Measures

Primary Outcomes (1)

• Lung Morphology

  Value of static MR-images compared to CT.

  2 years

Secondary Outcomes (1)

• Lung function

  2 years

Study Arms (1)

All patients

OTHER

There are no study arms. All patients obtain all imaging modalities.

Diagnostic Test: MRI of the chest

Interventions

MRI of the chest DIAGNOSTIC_TEST

The study participants will obtain a MRI of the thorax with one of the institutions MR machines (Philips Achieva 1.5T, GE Discovery 3T, MRI Siemens Skyra 3T, and GE SIGNA Artist 1.5T). The study participant will be asked to lie in the MR scanner for about 30 minutes while the images will be acquired. The image acquisition with the above-mentioned MR machines is authorised in Switzerland and the application is done according to the product information.

All patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients with interstitial lung disease scheduled for CT and LFT
• written consent
• ≥ 18 years.

You may not qualify if:

• claustrophobia
• impossibility to lie in the MR for more than 30 minutes
• pregnancy
• generally valid contraindications for MRI

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich - Diagnostic Radiology

Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Lung Diseases; Lung Diseases, Interstitial

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Prospective, single-centre, non-randomised, non-blinded trial with MR-Imaging of patients. All of the patients undergo MR-Imaging as well as the two standard diagnostic procedures: CT and lung function tests.

Study Record Dates

• First Submitted: January 20, 2021
• First Posted: January 22, 2021
• Study Start: June 1, 2023
• Primary Completion: July 31, 2023
• Study Completion: December 31, 2023
• Last Updated: May 11, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)