Adapting the HOPE Online Support Intervention to Increase Uptake of Medications for Opioid Use Disorder

NCT04712981 | Active Not Recruiting DMC

• 2 other identifiers: 202056254R33AT010606
• Study Type: interventional
• Target: 640
• Locations: 1 country
• Sites: 1

Brief Summary

In a randomized controlled trial, with 3, 6-month and 1-year follow-up, this application aims to explore whether and how the HOPE intervention can be adapted to increase MOUD uptake among OUD patients, assess the effectiveness of using HOPE to increase MOUD requests, and analyze online community data to improve future intervention implementation and sustainability.

Conditions

Opioid Use Disorder

Keywords

online community

Outcome Measures

Primary Outcomes (1)

• Number of requests to receive a resource on medications that can be used to treat opioid use disorder

  Participants will be invited to request an informational resource on medications for opioid use disorder as well as to ask for assistance scheduling an appointment with a provider on this topic. We will count the number of participants making this request

  request during the course of the 12-week community

Study Arms (2)

Intervention

EXPERIMENTAL

HOPE intervention peer-led online community

Behavioral: HOPE

Control

NO INTERVENTION

Online community without HOPE intervention psychological components

Interventions

HOPE BEHAVIORAL

Peer leaders/role models will be trained in HOPE intervention fundamentals and assigned to online community groups with participants.

Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ≥ 18 years of age;
• Resident of CA, NV, AZ, OR, WA;
• English speakers only;
• Has moderate to severe OUD;
• Is not currently prescribed MOUD;
• Reports using social media at least 2x per week;
• Has, or is willing to create a Facebook/social media account and accept a friend request and group invite from our study social media page

You may not qualify if:

• Was a participant in phase I of the study
• Participants with active, unstable opioid, alcohol, sedative, or other substance use and/or unstable medical or psychiatric conditions as assessed by the study questionnaires will be reviewed by the study physician consultants and will be excluded and referred for acute care including detoxification, if needed.

Sponsors & Collaborators

• National Center for Complementary and Integrative Health (NCCIH): collaborator
• University of California, Irvine: lead
• National Institutes of Health (NIH): collaborator

Study Sites (1)

University of California, Irvine

Irvine, California, 92617, United States

Location

MeSH Terms

Conditions

Opioid-Related Disorders

Condition Hierarchy (Ancestors)

Narcotic-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Sean D Young, PhD

  University of California, Irvine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 11, 2021
• First Posted: January 19, 2021
• Study Start: April 29, 2021
• Primary Completion: July 7, 2025
• Study Completion: May 1, 2026
• Last Updated: March 6, 2026

Record last verified: 2026-03

Locations

US (1)