NCT04711564|Completed
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Sponsor study identifier
observational
40
1 country
1
Study Start
March 29, 2018
Actual (reported)Primary Completion
March 25, 2020
Actual (reported)Study Completion
April 15, 2020
Actual (reported)Intravenous lipid emulsions contain a number of biologically active ingredients, but the most important are fatty acids. Different fatty acids can affect a number of different physiological processes in different ways in critically ill patients. Adipose tissue can play an important role in metabolic changes of critical illnesses and in adaptation to stress through structural as well as functional changes Although it is known that serum adipokine and cytokine response changes in critical sepsis patients, the factors affecting these changes and the metabolic consequences of these changes are not well defined. The aim of this study was to evaluate the effects of intravenous lipid emulsions on serum adipokine and cytokine levels in patients with sepsis. Secondly, this is to determine the adipokine and cytokine kinetics in the sepsis process and their relationship with mortality in patients with sepsis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 15, 2020
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 29, 2018
Actual (reported)March 25, 2020
Actual (reported)April 15, 2020
Actual (reported)January 13, 2021
Actual (reported)January 15, 2021
Actual (reported)Change of the adipokine in the first ten days in onset sepsis
Adipokines levels are assayed using a enzyme-linked immunosorbent assay
Baseline and 10 days
Intensive care unit length of stay
Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year
28-day mortality
28 day
Olive oil-based (Oliclinomel: 80% OO, 20% LCT provided in a complete all-in-one PN bag by Baxter) parenteral nutrition
Soybean-based (Kabiven: 100% LCT provided in a complete all-in-one PN bag)
Parenteral nutrition planned according to the requirements of the patients is given for ten days.
Parenteral nutrition planned according to the requirements of the patients is given for ten days.
Critically ill patients with sepsis aged 18-85 years given parenteral nutrition therapy
Karadeniz Technical University Medical Faculty Department of Anesthesiology and Reanimation
Trabzon, Turkey (Türkiye)
Adipokines (adiponectin, rezistin leptin and visfatin) and cytokines (IL-6, IL-10, IL-1β and TNF-α) in critically ill with sepsis
Melda Kangalgil, MSc
Karadeniz Technical University
Ahmet Oguzhan Kucuk, MD
Karadeniz Technical University
Asiye Ozdemir, MD
Karadeniz Technical University
Süleyman Caner Karahan, MD
Karadeniz Technical University
40 participants (actual enrollment reported by the registry).
First Submitted
January 13, 2021
First Posted
January 15, 2021
Study Start
March 29, 2018
Actual (reported)Effect of Enteral Genistein Supplementation in Sepsis
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Umitcan Ok, MD
Karadeniz Technical University
Hatice Bozkurt Yavuz, MD
Karadeniz Technical University
Primary Completion
March 25, 2020
Actual (reported)Study Completion
April 15, 2020
Actual (reported)Last Updated
January 15, 2021
Record last verified: 2021-01
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Source: ClinicalTrials.gov.
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