Assessment of Gonadal Functions in Uremic Male Patients

NCT04710238 | Unknown

• 1 other identifier: uremic hypogonadism
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) .
2. 2.Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin and free testosterone levels.

Conditions

ESRD

Keywords

uremic hypogonadism; free testosterone level; serum prolactin

Outcome Measures

Primary Outcomes (1)

• Study the prevalence of sexual dysfunction in male patients on hemodialysis .

  Knowning the degree of sexual dysfunctions prevalence in male patients on hemodialysis and evaluation of the associated factors of gonadal dysfunction in male patients on hemodialysis .

  base line

Eligibility Criteria

• Age: 18 Years - 60 Years
• Gender Eligibility Details: male patients aged 18-60 (sexualy active males )
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

male patients that were diagnosed to be ESRD on hemodialysis , newly diagnosed and patients on chronic hemodialysis for years

You may qualify if:

• Male patients.
• ESRD on chronic hemodialysis with GFR lower than 15ml/min /1.73 m2
• Age (18\_60)years old

You may not qualify if:

• Diabetic patients . 3-hypertesive patients . 3-Patients with primary infertility before the event of ESRD and Starting dialysis.
• Manifest hypothyroidism . 5-Patient with other causes that may lead to subfertility as varicocele . 6-patients with previous exposure to head and genital trauma , surgery or irradiation .

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Palmer BF, Clegg DJ. Gonadal dysfunction in chronic kidney disease. Rev Endocr Metab Disord. 2017 Mar;18(1):117-130. doi: 10.1007/s11154-016-9385-9.

  PMID: 27586847 BACKGROUND

• Antonucci M, Palermo G, Recupero SM, Bientinesi R, Presicce F, Foschi N, Bassi P, Gulino G. Male sexual dysfunction in patients with chronic end-stage renal insufficiency and in renal transplant recipients. Arch Ital Urol Androl. 2016 Jan 14;87(4):299-305. doi: 10.4081/aiua.2015.4.299.

  PMID: 26766802 BACKGROUND

• Foulks CJ, Cushner HM. Sexual dysfunction in the male dialysis patient: pathogenesis, evaluation, and therapy. Am J Kidney Dis. 1986 Oct;8(4):211-22. doi: 10.1016/s0272-6386(86)80029-4.

  PMID: 3532769 BACKGROUND

• Fiuk JV, Tadros NN. Erectile dysfunction in renal failure and transplant patients. Transl Androl Urol. 2019 Apr;8(2):155-163. doi: 10.21037/tau.2018.09.04.

  PMID: 31080776 RESULT

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

ali setohy hussien, M.B.B.ch

CONTACT

01020462809; setohy94@gmail.com

Manal Elsayed Ez eldeen, prof.

CONTACT

01005826070; manal_ezeldeen@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident physician ,internal medicine departement , nephrology unite

Study Record Dates

• First Submitted: September 27, 2020
• First Posted: January 14, 2021
• Study Start: February 1, 2021
• Primary Completion: January 30, 2022
• Study Completion: February 28, 2022
• Last Updated: January 14, 2021

Record last verified: 2021-01