Clinical and Dermoscopic Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriasis Patients' Nails

NCT04709354 | Completed

• 1 other identifier: 54022451-050.06.06
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the fingernail findings of the rheumatoid arthritis, spondylopathy and psoriatic arthritis patient groups with the fingernails of psoriasis patients clinically and dermatoscopically and investigates the benefit of dermoscopy in the differentiation of these patients.

Conditions

Psoriasis Circinata; Psoriatic Arthritis; Rheumatoid Arthritis; Spondylarthropathies; Psoriatic Nail

Keywords

Psoriasis; Psoriatic Arthritis; Psoriatic Nail; Dermoscopy

Outcome Measures

Primary Outcomes (4)

• Comparation of clinical features of nails

  All of patients' fingernails will be examined clinically and visible nail findings will be noted. Many findings such as onycholysis, pitting, splinter hemorrhage, nail base vascularity, leukonychia etc. will be recorded. Also, the severity of nail involvement in psoriasis patients will be measured by the NAPSI score

  six months

• Comparation of dermoscopic features of nails

  All of patients' fingernails will be examined by dermoscopy and nail findings will be noted. Also in particular, vascularization around the nail will be checked and images of all of the findings will be taken. Rheumatoid arthritis and spondylopathy patients with nail findings consistent with psoriasis will be enrolled.

  six months

• NAPSI (Psoriasis Area and Severity index)

  All psoriasis patients will be scored on their nails with NAPSI (Psoriasis Area and Severity Index) scoring system. The correlation of PASI and NAPSI will be examined.

  six months

• PASI (Psoriasis Area and Severity Index)

  Skin lesions of all psoriasis patients will be scored with the PASI (Psoriasis Area and Severity Index) system. The correlation of PASI and NAPSI will be examined.

  six months

Secondary Outcomes (1)

• Demographic characteristics

  through study completion, an average of 6 months

Study Arms (4)

rheumatoid arthritis patient

Skin and fingernail examination of newly diagnosed (diagnosed before 1 year) rheumatoid arthritis patients will be done. A detailed dermoscopic examination will be performed on the nails of these patients.

Diagnostic Test: Dermoscopic examination

patients with spondylopathy

Skin and fingernail examination of newly diagnosed (diagnosed before 1 year) patient with spondylopathy will be done. A detailed dermoscopic examination will be performed on the nails of these patients.

Diagnostic Test: Dermoscopic examination

psoriatic arthritis

Skin and fingernail examination of patient with psoriatic arthritis will be done. A detailed dermoscopic examination will be performed on the nails of these patients. PASI and NAPSI scores of all patients will be calculated.

Diagnostic Test: Dermoscopic examination

psoriasis patients without joint involvement

Skin and fingernail examination of patient with psoriasis patients without joint involvement will be done. A detailed dermoscopic examination will be performed on the nails of these patients. PASI and NAPSI scores of all patients will be calculated.

Diagnostic Test: Dermoscopic examination

Interventions

Dermoscopic examination DIAGNOSTIC_TEST

The periungual area, nail plate, subungual area of the patients' fingernails will be examined and images of the lesional nails or target nails will be recorded for comparison.

patients with spondylopathy; psoriasis patients without joint involvement; psoriatic arthritis; rheumatoid arthritis patient

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients over 18 years with psoriasis, rheumatoid arthritis, ankylosing spondylitis

You may qualify if:

• Psoriasis confirmed by dermatologist.
• Rheumatoid arthritis, ankylosing spondylitis confirmed by rheumatologist (newly diagnosed).

You may not qualify if:

• Unable to consent and understand
• Patients with confirmed onychomycosis
• Patients receiving biological therapy

Sponsors & Collaborators

• Bezmialem Vakif University: lead

Study Sites (1)

Bezmialem Vakıf Univesity

Istanbul, 34093, Turkey (Türkiye)

Location

Related Publications (3)

• Yorulmaz A, Artuz F. A study of dermoscopic features of nail psoriasis. Postepy Dermatol Alergol. 2017 Feb;34(1):28-35. doi: 10.5114/ada.2017.65618. Epub 2017 Feb 7.

  PMID: 28286468 RESULT

• Wanniang N, Navya A, Pai V, Ghodge R. Comparative Study of Clinical and Dermoscopic Features in Nail Psoriasis. Indian Dermatol Online J. 2020 Jan 13;11(1):35-40. doi: 10.4103/idoj.IDOJ_51_19. eCollection 2020 Jan-Feb.

  PMID: 32055506 RESULT

• Zabotti A, Errichetti E, Zuliani F, Quartuccio L, Sacco S, Stinco G, De Vita S. Early Psoriatic Arthritis Versus Early Seronegative Rheumatoid Arthritis: Role of Dermoscopy Combined with Ultrasonography for Differential Diagnosis. J Rheumatol. 2018 May;45(5):648-654. doi: 10.3899/jrheum.170962. Epub 2018 Feb 15.

  PMID: 29449498 RESULT

MeSH Terms

Conditions

Arthritis, Psoriatic; Arthritis, Rheumatoid; Spondylarthropathies; Psoriasis

Condition Hierarchy (Ancestors)

Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Rheumatic Diseases; Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Nahide MD Onsun, Prof

  Bezmialem University

  STUDY DIRECTOR

• Begüm MD Güneş

  Bezmialem University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2021
• First Posted: January 14, 2021
• Study Start: January 1, 2021
• Primary Completion: November 20, 2021
• Study Completion: December 20, 2021
• Last Updated: December 22, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)