NCT04709146

Brief Summary

the study's porpuse is to examine whether Covid-19 causese a reduction in sensorineural hearing and vestibular function in recovered pateints - compared to healthy controls. Both study groups will undergo audiometry, tympanometry, Video Head Impulse testing, Subjective Visual Vertigo testing and Video-Nystamography. Previous audiometry results will also be aquired.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
70

participants targeted

Target at P25-P50 for not_applicable covid19

Timeline
Completed

Started Mar 2021

Typical duration for not_applicable covid19

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 11, 2021

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 14, 2021

Completed
2 months until next milestone

Study Start

First participant enrolled

March 1, 2021

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2022

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2022

Completed
Last Updated

January 14, 2021

Status Verified

January 1, 2021

Enrollment Period

12 months

First QC Date

January 11, 2021

Last Update Submit

January 13, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • sensoneural hearing level - PTA

    PTA at each frequency will be compared between new and baseline audiogram for each group. Afterwhich - the average PTA decreament would be compared betwenn both groups - contrl and recovered COVID-19 patients

    through study completion, an average of 1 year

Secondary Outcomes (1)

  • vestibular function

    through study completion, an average of 1 year

Study Arms (2)

Recovered Covid-19 patients

OTHER

Diagnostic evulation with audiometry, Tympanography, SVV, VHIT, VNG.

Diagnostic Test: Audio-Vestibular evaluation

Healthy Control

OTHER

Diagnostic evulation with audiometry, Tympanography, SVV, VHIT, VNG.

Diagnostic Test: Audio-Vestibular evaluation

Interventions

Diagnostic evulation with audiometry, Tympanography, SVV, VHIT, VNG.

Healthy ControlRecovered Covid-19 patients

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ages 18-80 performed audiometry testing in the last two years

You may not qualify if:

  • known inner ear dysfunction - Sudden sensorineural hearing loss; autoimmune disease (Cogan's syndrom, SLE, ect.), familial/genetic sensorineural hearing loss, excessive noise exposure.
  • knowm conductive hearing loss (Air-bone gap\>10dB) prior ear surgery chronic tympanic membrane perforation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Central Study Contacts

Yoni Evgeni Gutkovich, M.D/Ph.D

CONTACT

Miki Paker, M.D

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
M.D/Ph.D.

Study Record Dates

First Submitted

January 11, 2021

First Posted

January 14, 2021

Study Start

March 1, 2021

Primary Completion

February 28, 2022

Study Completion

June 30, 2022

Last Updated

January 14, 2021

Record last verified: 2021-01

Data Sharing

IPD Sharing
Will not share