Effects of Aerobic Exercise Modulation on Brain Physiology and Cognition in Young Adults With Depression

NCT04708691 | Unknown DMC

• 1 other identifier: 201911100RIND
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Major depressive depression (MDD) affects a quarter of young adults and is associated with marked global burden in this population. Recently, growing literature has shown that cognitive dysfunction is common in young adults with depression. There is a vast amount of evidence indicating aerobic exercise has positive effects on cognitive function in healthy as well as in subjects with depression. The results might be dependent on neuroplastic changes induced by aerobic exercise. Nevertheless, the neurocognitive mechanisms of aerobic exercise in young adults with depression has not received systematic investigation. In addition, the association between the underlying brain physiology and cognitive performance has not been explored so far. In this project, the investigators aim to explore the relevance of a single session of aerobic exercise for human brain physiology and the impact of respective physiological effects on cognitive processes in young adults with depression.

Conditions

Depression

Keywords

Depression; Neurophysiology; Cognition

Outcome Measures

Primary Outcomes (1)

• Cortical excitability

  TMS measurment

  4 weeks

Secondary Outcomes (1)

• Cognitive task

  4 weeks

Study Arms (2)

Aerobic exercise

EXPERIMENTAL

aerobic exercise for 30 mins

Other: Aerobic exercise

Control

NO INTERVENTION

sitting for 30 mins

Interventions

Aerobic exercise OTHER

aerobic exercise

Aerobic exercise

Eligibility Criteria

• Age: 20 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Diagnosis of major depressive disorder by a board-certified psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
• Total score of the 17-item Hamilton Rating Scale for Depression (HAM-D) less than 7
• Aged between 18 to 35 years
• Right handedness

You may not qualify if:

• A major depressive episode within the past three months
• Pacemaker or deep brain stimulation
• Metal implants in the head or neck area
• Other major mental disorders including autism spectrum disorders, mental retardation, psychotic disorders, bipolar disorders, obsessive-compulsive disorder, and neurocognitive disorders
• Alcohol or other illicit substance abuse
• Neurological diseases involving the central nervous system
• Major debilitating systemic diseases
• Pregnancy
• Breast feeding
• Cigarette smoker
• Color blindness
• Take part in another study within the last 4 weeks

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Conditions

Depression

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Kuo Hsiao-I, PHD

  Assistant Professor, National Taiwan University

  PRINCIPAL INVESTIGATOR

• Kuo Hsiao-I

  Assistant Professor, National Taiwan University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kuo Hsiao-I, PhD

CONTACT

02-33668137; hikuo@ntu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 12, 2021
• First Posted: January 14, 2021
• Study Start: May 1, 2020
• Primary Completion: April 1, 2023
• Study Completion: April 1, 2023
• Last Updated: September 10, 2021

Record last verified: 2021-05

Locations

TW (1)