Platelet-activation and Optimal Inhibition in Patients With Atrial Fibrillation Undergoing Left Atrial Appendage Occlusion

You may not qualify if:

• Unable or unwilling to return for required follow-up visits and examinations
• Mechanical heart valves or valvular disease requiring surgery or interventional procedure
• Ongoing major bleeding or complicated or recent (\<72hours) major surgery
• Known large oesophageal varices or decompensated liver disease (unless a documented positive opinion of a gastro-enterologist)
• Severe thrombocytopenia (\<50,000/ml)
• High likelihood of being unavailable for follow-up or psycho-social condition making study participation impractical.
• Woman with child bearing potential who do not use an efficient method of contraception.
• Positive serum or urine pregnancy test for woman with child bearing potential
• Pregnancy or within 48 hours post-partum
• unsuitable LAA anatomy for occlusion or thrombus in the LAA at the time of procedure
• contraindications or unfavourable conditions to perform cardiac catheterization or transesophageal echocardiography (TEE)
• atrial septal malformations, atrial septal defect or a high-risk patent foramen ovale that may cause thrombo-embolic events
• atrial septal defect repair or closure device or a patent foramen ovale repair or any other anatomical condition as this may preclude an LAAO procedure
• Mitral valve regurgitation grade 3 or more
• Aortic valve stenosis (AVA\<1.0 cm2 or Pmax\>50 mmHg) or regurgitation grade 3 or more
• +2 more criteria