The Effect of Whole Blood Viscosity on Contrast-Induced Nephropathy Development in Patients Undergoing Percutaneous Coronary Intervention

NCT04703049 | Completed

• 1 other identifier: YİEAH
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

In our study, we aimed to investigate how whole blood viscosity (WBV) affects the development of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI).

Conditions

Percutaneous Coronary Intervention Patients

Keywords

Viscosity; Contrast; Nephropathy; Coronary Intervention

Outcome Measures

Primary Outcomes (1)

• Contrast Induced Nephropathy

  CIN was defined as an increase in serum creatinine levels greater than 0.5 mg/dl or 25% or more increase compared to basal serum creatinine levels 48 to 72 h after exposure.

  48 to 72 hours

Interventions

Blood Viscosity Testing OTHER

we calculated WBV using the formula \[(0.12 × hematocrit) + (0.17 × (total protein - 2.07)\]. We defined CIN as the absolute (≥0.5 mg/dl) or relative increase (≥25%) in serum creatinine 48-72 h after exposure to a contrast agent compared with baseline serum creatinine values.

Eligibility Criteria

• Age: 18 Years - 90 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study started with the approval of the local ethics committee. Five hundred patients between ages 18 and 90 who underwent PCI in our hospital between July 10, 2017, and October 31, 2017, were prospectively included. Informed consent forms were obtained from the patients. Patients with chronic kidney disease (CKD) who underwent hemodialysis or peritoneal dialysis for this reason and patients who underwent to coronary bypass surgery within 48 h were excluded from the study.

You may qualify if:

• patients between ages 18 and 90
• underwent PCI in our hospital between

You may not qualify if:

• Patients with chronic kidney disease (CKD) who underwent hemodialysis or peritoneal dialysis
• Patients who underwent to coronary bypass surgery within 48 h were excluded from the study.

Sponsors & Collaborators

• Bursa Postgraduate Hospital: lead

Study Sites (1)

Bursa Yüksek İhtisas Hastanesi

Bursa, None Selected, 16320, Turkey (Türkiye)

Location

Related Publications (2)

• Camci S, Kinik M, Ari S, Ari H, Melek M, Bozat T. The predictive value of hemoglobin to creatinine ratio for contrast-induced nephropathy in percutaneous coronary interventions. Clin Chem Lab Med. 2022 Jun 22;60(9):1455-1462. doi: 10.1515/cclm-2022-0247. Print 2022 Aug 26.

  PMID: 35727209 DERIVED

• Kinik M, Camci S, Ari S, Ari H, Melek M, Bozat T. The effect of whole blood viscosity on contrast-induced nephropathy development in patients undergoing percutaneous coronary intervention. Postgrad Med. 2022 Jan;134(1):78-84. doi: 10.1080/00325481.2021.1997007. Epub 2021 Nov 10.

  PMID: 34670475 DERIVED

MeSH Terms

Conditions

Kidney Diseases

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Doctor

Study Record Dates

• First Submitted: January 7, 2021
• First Posted: January 11, 2021
• Study Start: July 10, 2017
• Primary Completion: October 31, 2017
• Study Completion: November 30, 2017
• Last Updated: August 13, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)