Canadian COVID-19 Emergency Department Registry

NCT04702945 | Unknown

• 1 other identifier: H20-01015
• Study Type: observational
• Target: 200,000
• Locations: 1 country
• Sites: 50

Brief Summary

Coronavirus Disease 2019 (COVID -19) is the largest public health crisis in over a century. There is an urgent need for high-quality population-level data to understand modifiable risks for disease severity, transmissibility, and to develop evidence-based prevention (i.e. vaccination), treatment and resource allocation strategies. The Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) created a population-based registry of suspected and confirmed consecutive cases of COVID-19. The purpose of this registry is to derive and validate clinical decision rules, evaluate diagnostic tests and vaccine effectiveness, and complete cohort, case-control and observational studies to inform the pandemic response.

Conditions

Covid-19

Keywords

Coronavirus; Infectious diseases; Registry

Outcome Measures

Primary Outcomes (1)

• Confirmed COVID-19 diagnosis

  Biological specimen is tested positive for SARS-CoV-2 using reverse transcription polymerase chain reaction (RT PCR). The specimen had to be drawn within two weeks of the emergency department visit if the patient presented with a COVID-19-related complication. If the initial test was negative, the patient had to have a positive specimen within 14 days of the index visit.

  14 days

Secondary Outcomes (7)

• Hospital admission

  30 days

• Mechanical ventilation

  30 days

• Emergency department revisits

  30 days

• Hospital re-admissions

  30 days

• 30 day mortality

  30 days

Study Arms (1)

Registry participants

Patients presenting to participating emergency departments with suspected and or confirmed COVID-19.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting to participating Canadian emergency departments with suspected and or confirmed COVID-19.

You may qualify if:

• Meeting the WHO suspect COVID-19 criteria: Fever (self-reported or subjective fever) and at least one symptom/sign of respiratory illness (e.g., flu-like illness, cough, shortness of breath)
• Presenting to the emergency department and tested for COVID-19 in the emergency department

You may not qualify if:

• Period 2 started on the date which each province expanded testing criteria allowing clinicians to test patients based on clinical suspicion or policy.
• Presenting to the emergency department within 14 days of a positive COVID-19 (by self-report or in medical chart) and presents with clinical symptoms consistent with COVID-19
• Tested for COVID-19 in the emergency department, or within 24 hours after emergency department arrival.
• Patients tested for COVID-19 in the context of an elective admission (e.g., planned hip revision)
• Patients tested for COVID-19 and seen in the emergency department directly by another service (e.g., trauma team activation)

Sponsors & Collaborators

• University of British Columbia: lead
• Genome British Columbia: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator
• Canadian Critical Care Trials Group: collaborator

Study Sites (50)

Foothills Medical Centre

Calgary, Alberta, Canada

RECRUITING

Peter Lougheed Centre

Calgary, Alberta, Canada

RECRUITING

Rockyview General Hospital

Calgary, Alberta, Canada

RECRUITING

South Health Campus

Calgary, Alberta, Canada

RECRUITING

Northeast Community Health Centre

Edmonton, Alberta, Canada

RECRUITING

Royal Alexandra Hospital

Edmonton, Alberta, Canada

RECRUITING

University of Alberta Hospital

Edmonton, Alberta, Canada

RECRUITING

Abbotsford Regional Hospital

Abbotsford, British Columbia, Canada

RECRUITING

Royal Inland Hospital

Kamloops, British Columbia, Canada

RECRUITING

Kelowna General Hospital

Kelowna, British Columbia, Canada

RECRUITING

Royal Columbian Hospital

New Westminster, British Columbia, Canada

RECRUITING

Lions Gate Hospital

North Vancouver, British Columbia, Canada

RECRUITING

Eagle Ridge Hospital

Port Moody, British Columbia, Canada

RECRUITING

Surrey Memorial Hospital

Surrey, British Columbia, Canada

RECRUITING

Mount Saint Joseph Hospital

Vancouver, British Columbia, Canada

RECRUITING

St. Paul's Hospital

Vancouver, British Columbia, Canada

RECRUITING

Vancouver General Hospital

Vancouver, British Columbia, Canada

RECRUITING

Saint John Regional Hospital

Saint John, New Brunswick, Canada

RECRUITING

Dartmouth General Hospital

Dartmouth, Nova Scotia, Canada

RECRUITING

Halifax Infirmary

Halifax, Nova Scotia, Canada

RECRUITING

Cobequid Community Health Centre

Lower Sackville, Nova Scotia, Canada

RECRUITING

Hants Community Hospital

Windsor, Nova Scotia, Canada

RECRUITING

Health Science North

Greater Sudbury, Ontario, Canada

RECRUITING

Hamilton General Hospital

Hamilton, Ontario, Canada

RECRUITING

Juravinski Hospital

Hamilton, Ontario, Canada

RECRUITING

Hotel Dieu Hospital

Kingston, Ontario, Canada

RECRUITING

Kingston General Hospital

Kingston, Ontario, Canada

RECRUITING

London Health Sciences Centre (University Hospital)

London, Ontario, Canada

RECRUITING

London Health Sciences Centre (Victoria Hospital)

London, Ontario, Canada

RECRUITING

The Ottawa Hospital - Civic Campus

Ottawa, Ontario, Canada

RECRUITING

The Ottawa Hospital - General Campus

Ottawa, Ontario, Canada

RECRUITING

North York General Hospital

Toronto, Ontario, Canada

RECRUITING

Sunnybrook Hospital

Toronto, Ontario, Canada

RECRUITING

Toronto Western Hospital

Toronto, Ontario, Canada

RECRUITING

Hôtel-Dieu de Lévis

Lévis, Quebec, Canada

RECRUITING

Hôpital du Sacré-Coeur

Montreal, Quebec, Canada

RECRUITING

Jewish General Hospital

Montreal, Quebec, Canada

RECRUITING

Montréal General Hospital (MUHC)

Montreal, Quebec, Canada

RECRUITING

Royal Victoria Hospital (MUHC)

Montreal, Quebec, Canada

RECRUITING

Centre Hospitalier de l'Université Laval (CHU de Québec)

Québec, Quebec, Canada

RECRUITING

Hôpital de l'Enfant-Jésus (CHU de Québec)

Québec, Quebec, Canada

RECRUITING

Hôpital du Saint-Sacrement (CHU de Québec)

Québec, Quebec, Canada

RECRUITING

Hôpital Saint-François d'Assise (CHU de Québec)

Québec, Quebec, Canada

RECRUITING

Hôtel-Dieu de Québec (CHU de Québec)

Québec, Quebec, Canada

RECRUITING

Institut universitaire de cardiologie et de pneumologie de Québec

Québec, Quebec, Canada

RECRUITING

Pasqua Hospital

Regina, Saskatchewan, Canada

RECRUITING

Regina General Hospital

Regina, Saskatchewan, Canada

RECRUITING

Royal University

Saskatoon, Saskatchewan, Canada

RECRUITING

Saskatoon City Hospital

Saskatoon, Saskatchewan, Canada

RECRUITING

St Paul's Hospital

Saskatoon, Saskatchewan, Canada

RECRUITING

Related Publications (9)

• Rosychuk RJ, Khangura JK, Ortiz SS, Cheng I, Bielska IA, Yan J, Morrison LJ, Hayward J, Grant L, Hohl CM; Canadian COVID-19 Rapid Response Network (CCEDRRN) for the Network of Canadian Emergency Researchers (NCER). Characteristics and outcomes of patients with COVID-19 who return to the emergency department: a multicentre observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). Emerg Med J. 2024 Mar 21;41(4):210-217. doi: 10.1136/emermed-2023-213277.

  PMID: 38365437 DERIVED

• Hohl CM, Cragg A, Purssell E, McAlister FA, Ting DK, Scheuermeyer F, Stachura M, Grant L, Taylor J, Kanu J, Hau JP, Cheng I, Atzema CL, Bola R, Morrison LJ, Landes M, Perry JJ, Rosychuk RJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study. PLoS One. 2023 Sep 26;18(9):e0291580. doi: 10.1371/journal.pone.0291580. eCollection 2023.

  PMID: 37751455 DERIVED

• Archambault PM, Rosychuk RJ, Audet M, Bola R, Vatanpour S, Brooks SC, Daoust R, Clark G, Grant L, Vaillancourt S, Welsford M, Morrison LJ, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Accuracy of Self-Reported COVID-19 Vaccination Status Compared With a Public Health Vaccination Registry in Quebec: Observational Diagnostic Study. JMIR Public Health Surveill. 2023 Jun 16;9:e44465. doi: 10.2196/44465.

  PMID: 37327046 DERIVED

• Lin K, Xu K, Daoust R, Taylor J, Rosychuk RJ, Hau JP, Davis P, Clark G, McRae AD, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, the Canadian Critical Care Trials Group. Prognostic association between d-dimer thresholds and 30-day pulmonary embolism diagnosis among emergency department patients with suspected SARS-CoV-2 infection: a Canadian COVID-19 Emergency Department Rapid Response Network study. CJEM. 2023 Feb;25(2):134-142. doi: 10.1007/s43678-022-00440-8. Epub 2023 Jan 10.

  PMID: 36624252 DERIVED

• Davis P, Rosychuk R, Hau JP, Cheng I, McRae AD, Daoust R, Lang E, Turner J, Khangura J, Fok PT, Stachura M, Brar B, Hohl CM; CCEDRRN investigators, and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study. BMJ Open. 2022 Aug 10;12(8):e057852. doi: 10.1136/bmjopen-2021-057852.

  PMID: 35948378 DERIVED

• Hohl CM, Rosychuk RJ, Hau JP, Hayward J, Landes M, Yan JW, Ting DK, Welsford M, Archambault PM, Mercier E, Chandra K, Davis P, Vaillancourt S, Leeies M, Small S, Morrison LJ; Canadian COVID-19 Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, for the Canadian Critical Care Trials Group. Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). CJEM. 2022 Jun;24(4):397-407. doi: 10.1007/s43678-022-00275-3. Epub 2022 Apr 1.

  PMID: 35362857 DERIVED

• Hohl CM, Rosychuk RJ, Archambault PM, O'Sullivan F, Leeies M, Mercier E, Clark G, Innes GD, Brooks SC, Hayward J, Ho V, Jelic T, Welsford M, Sivilotti MLA, Morrison LJ, Perry JJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. The CCEDRRN COVID-19 Mortality Score to predict death among nonpalliative patients with COVID-19 presenting to emergency departments: a derivation and validation study. CMAJ Open. 2022 Feb 8;10(1):E90-E99. doi: 10.9778/cmajo.20210243. Print 2022 Jan-Mar.

  PMID: 35135824 DERIVED

• McRae AD, Hohl CM, Rosychuk R, Vatanpour S, Ghaderi G, Archambault PM, Brooks SC, Cheng I, Davis P, Hayward J, Lang E, Ohle R, Rowe B, Welsford M, Yadav K, Morrison LJ, Perry J; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19. BMJ Open. 2021 Dec 2;11(12):e055832. doi: 10.1136/bmjopen-2021-055832.

  PMID: 34857584 DERIVED

• Hohl CM, Rosychuk RJ, McRae AD, Brooks SC, Archambault P, Fok PT, Davis P, Jelic T, Turner JP, Rowe BH, Mercier E, Cheng I, Taylor J, Daoust R, Ohle R, Andolfatto G, Atzema C, Hayward J, Khangura JK, Landes M, Lang E, Martin I, Mohindra R, Ting DK, Vaillancourt S, Welsford M, Brar B, Dahn T, Wiemer H, Yadav K, Yan JW, Stachura M, McGavin C, Perry JJ, Morrison LJ; Canadian COVID-19 Emergency Department Rapid Response Network investigators and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study. CMAJ Open. 2021 Mar 17;9(1):E261-E270. doi: 10.9778/cmajo.20200290. Print 2021 Jan-Mar.

  PMID: 33731427 DERIVED

MeSH Terms

Conditions

COVID-19; Coronavirus Infections; Communicable Diseases

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Corinne M Hohl, MD, MSc

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Corinne M Hohl, MD, MSc

CONTACT

604-875-4111; corinne.hohl@ubc.ca

Laurie Morrison, MD,MSc

CONTACT

416-864-6060; Laurie.Morrison@unityhealth.to

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 6, 2021
• First Posted: January 11, 2021
• Study Start: March 1, 2020
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2023
• Last Updated: January 11, 2021

Record last verified: 2021-01

Locations

CA (50)