Smoking Effect on Lumbar Intervertebral Disc Degeneration

NCT04702126 | Completed

• 1 other identifier: FSMTRHU
• Study Type: observational
• Target: 360
• Locations: 1 country
• Sites: 2

Brief Summary

Besides normal aging, genetic and environmental factors are important potential determinants of lumbar disc degeneration. Smoking causes serious health problems, particularly lung and other cancers, heart disease and respiratory diseases, and is among the most common causes of death worldwide. Besides these commonly known diseases related to smoking numerous studies have shown that smoking has detrimental effects on the musculoskeletal system and worsens the prognosis and treatment of leukomotor diseases. In the literature there are studies examining the effect of smoking status on disc degeneration. The aim of the study was to investigate the effect of current, former and passive smoking status on degeneration of lumbar intervertebral discs.

Conditions

Intervertebral Disc Degeneration

Keywords

Intervertebral disc degeneration; Magnetic resonance imaging; Smoking; Passive smoker

Outcome Measures

Primary Outcomes (1)

• Evaluation of the effect of current, former and passive smoking status on degeneration of lumbar intervertebral discs.

  The lumbar intervertebral discs of patients were evaluated by Pfirrmann disc degeneration grading system using sagittal T2-weighted MR images. The degree of degeneration was classified into five grades with Grades IV and V considered as "severe disc degeneration". Severe disc degeneration was identified between the current, former, passive and non-smoker groups. The relationship between smoking status groups and severe disc degeneration was examined.

  3 months

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent lumbar spinal MRI between September 2019 and February 2020 and questioned for smoking status.

You may qualify if:

• Patients who underwent lumbar spinal MRI between September 2019 and February 2020.

You may not qualify if:

• a history of spinal surgery or instrumentation, spinal fracture, trauma, congenital or acquired spinal deformity tumor or infection,
• heavy physical workers,
• athletes

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (2)

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, 34758, Turkey (Türkiye)

Location

Fatih Sultan Mehmet Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Intervertebral Disc Degeneration; Smoking

Condition Hierarchy (Ancestors)

Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Behavior

Study Officials

• Fatma Esra Bahadir Ülger, M.D.

  Fatih Sultan Mehmet Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Fatih Sultan Mehmet Training and Research Hospital

Study Record Dates

• First Submitted: January 5, 2021
• First Posted: January 8, 2021
• Study Start: September 1, 2019
• Primary Completion: February 1, 2020
• Study Completion: February 1, 2020
• Last Updated: January 8, 2021

Record last verified: 2021-01

Locations

TU (2)