Investigation of Immune Modulation by Modern Acupuncture in Gastroenterologic Cancers

NCT04692454 | Completed

• 1 other identifier: N202005058
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

According to the total population of cancer patients, hepatocellular carcinoma (HCC) and colorectal cancer (CRC), two of gastroenterological cancers are involved in the most acquired five cancers. Colorectal cancer (CRC) is a leading cause of tumor-related morbidity and mortality worldwide, and HCC is one of the top ten cancers in China. Currently, the intervention for gastrointestinal cancers mainly focuses on surgical removal, but patients still have a high risk of recurrence. Thus, the prevention of cancer recurrence is the most crucial topic for the intervention. The pathophysiology of gastroenterological cancers is multifactorial and not yet completely understood. However, immunosuppression is a major contributing factor in tumor cells play a central part in disease progression. It determines the prognosis of patients.

Conditions

Hepatocellular Cancer; Gastrointestinal Cancer; Immunosuppression

Keywords

gastrointestinal; Hepatocellular; immunosuppression; acupuncture

Outcome Measures

Primary Outcomes (1)

• The number of CD8+ T

  Using PBMC to analyze the number of CD8+ T that is NK, NKT, DC, and Monocyte. At the start of acupuncture adjuvant therapy (week 0, week 2, and week 4) blood was collected. Blood draw - 15 ml/each Week0- baseline, the original data of CD8+T before receiving acupuncture Week2- the data of CD8+T after receiving acupuncture Week4- the data of CD8+T after two weeks that the patients did not receive acupuncture Compare with week0 and week2 data, if week2 data is higher than week0, it means the acupuncture has effective to add the number of CD8+ T. Compare with week 2 and week 4 data results and confirm the data change of the number of CD8+ T after stopping the acupuncture. If the data do not decline, it means the effect of acupuncture remains to exist. If the data declines, it means the effect of acupuncture weakens.

  4 weeks

Study Arms (1)

the scalp and ear acupuncture

EXPERIMENTAL

CHIAN HUEI ACUPUNCTURE NEEDLE

Other: Modern acupuncture

Interventions

Modern acupuncture OTHER

use the scalp and ear acupuncture methods to identify diseases and checkpoints and apply them to regulate the immune function of patients with gastroenterological cancers.

the scalp and ear acupuncture

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of gastrointestinal cancer
• Must have the will to receive acupuncture

You may not qualify if:

• Clinical diagnosis of Late cancer
• History of having bad reflect in acupuncture
• Coagulopathy

Sponsors & Collaborators

• Taipei Medical University WanFang Hospital: lead

Study Sites (1)

WanFangH

Taipei, 116, Taiwan

Location

MeSH Terms

Conditions

Liver Neoplasms; Gastrointestinal Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Liver Diseases; Gastrointestinal Diseases

Study Officials

• Ming-Shun Wu, PHD

  Taipei Municipal Wanfang Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of GI

Study Record Dates

• First Submitted: December 16, 2020
• First Posted: December 31, 2020
• Study Start: August 31, 2020
• Primary Completion: November 30, 2020
• Study Completion: November 30, 2020
• Last Updated: December 31, 2020

Record last verified: 2020-12

Locations

TW (1)