Biomarkers in Thoracic Aorta Surgery

NCT04689139 | Completed Results DMC

• 1 other identifier: 039420200002
• Study Type: interventional
• Target: 132
• Locations: 1 country
• Sites: 1

Brief Summary

Biomarkers can play a vital role in prognosing the perioperative complications in thoracic aorta surgery. The goal of a study is to determine the correlation between intraoperative level of certain biomarkers and total amount of peroperative complications.

Conditions

Aortic Aneurysm; Thoracoabdominal Aneurysm; Aortic Dissection; Complication

Outcome Measures

Primary Outcomes (1)

• Number of Total Postoperative Complications

  Value reported in the Outcome Measure data table reflects the Number of Total Postoperative Complications across all participants.

  up to 10 days

Secondary Outcomes (5)

• Total Number Affected by All-Cause Mortality

  up to 10 days

• Number of Participants Who Require Extracorporeal Detoxication

  up to 10 days

• Number of Cardiac Disorders

  up to 10 days

• Number of Vascular Disorders

  up to 10 days

• Number of Infections and Infestations

  up to 10 days

Study Arms (1)

Thoracic aorta surgery patients

EXPERIMENTAL

Blood samples on proadrenomedullin, presepsin, NT-proBNP, Troponin I, procalcitonin are acquired

Diagnostic Test: blood sample tests for determination of biomarkers levels

Interventions

blood sample tests for determination of biomarkers levels DIAGNOSTIC_TEST

Using of proadrenomedullin, presepsin, NT-proBNP, Troponin I to determine the correlation of perioperative complications.

Thoracic aorta surgery patients

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Elective thoracic and thoracoabdominal surgery

You may not qualify if:

• Hemolysis in blood sample

Sponsors & Collaborators

• Petrovsky National Research Centre of Surgery: lead

Study Sites (1)

Petrovsky Research National Centre of Surgery ( Petrovsky NRCS)

Moscow, 119991, Russia

Location

Related Links

• Assessing the significance of some biomarkers in perioperative period after thoracic aortic reconstruction

MeSH Terms

Conditions

Aortic Aneurysm; Aortic Dissection

Condition Hierarchy (Ancestors)

Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Dissection, Blood Vessel; Acute Aortic Syndrome

Results Point of Contact

• Title: Dr. Artem Gubko
• Organization: Petrovsky NRCS

gubko@artvig.ru

+79684241490

Study Officials

• Boris Akselrod, Professor

  Petrovsky NRCS

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 22, 2020
• First Posted: December 30, 2020
• Study Start: March 1, 2021
• Primary Completion: February 1, 2022
• Study Completion: May 1, 2022
• Last Updated: September 19, 2024
• Results First Posted: May 6, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

RU (1)