Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis

NCT04685031 | Unknown Phase 1 DMC

• 1 other identifier: KomarUST
• Study Type: interventional
• Target: 110
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study was to determine the effect of Clobetasol ointment with nitroglycerin ointment on the prevention of superficial phlebitis caused by cannulation. This clinical trial was conducted on 110 patients admitted to the surgical ward, in three groups of Clobetasol, nitroglycerin, and control. The data collection tools included demographic information, information about intravenous treatment and phlebitis measurement scale. In the intervention groups, after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

Conditions

Phlebitis

Keywords

Nitroglycerine; Clobetasol; phlebitis

Outcome Measures

Primary Outcomes (1)

• Demographic information questionnaire

  age and type of disease

  72 hours

Secondary Outcomes (1)

• The visual scale of phlebitis

  72hours

Study Arms (3)

nitroglycerin

EXPERIMENTAL

after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

Drug: Nitroglycerin ointment; Drug: Clobetasol Topical

clobetasol

EXPERIMENTAL

after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

Drug: Nitroglycerin ointment; Drug: Clobetasol Topical

routine

NO INTERVENTION

routine nursing care

Interventions

Nitroglycerin ointment DRUG

after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

clobetasol; nitroglycerin

Clobetasol Topical DRUG

after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

clobetasol; nitroglycerin

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• must be older than 18 years old
• must be in need of hospitalization at least 72 hours
• does not state any previous allergic reaction to the ointments
• does not use any types of drug that can hurts veins (chemotherapy drugs, diazepam. amiodarone, and....)

You may not qualify if:

• active infection
• discharge from hospital sooner than 72 hours
• displacement of cannula before 72 hours

Sponsors & Collaborators

• Komar University of Science and Technology: lead

MeSH Terms

Conditions

Phlebitis

Interventions

Clobetasol

Condition Hierarchy (Ancestors)

Peripheral Vascular Diseases; Vascular Diseases; Cardiovascular Diseases; Vasculitis

Intervention Hierarchy (Ancestors)

Betamethasone; Steroids, Fluorinated; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator,nursing department

Study Record Dates

• First Submitted: December 4, 2020
• First Posted: December 28, 2020
• Study Start: February 1, 2021
• Primary Completion: April 1, 2021
• Study Completion: May 1, 2021
• Last Updated: December 28, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share