Using Microbiome to Predict Durvalumab Toxicity in Post- Concurrent Chemoradiation Therapy (CCRT) NSCLC Patients

You may not qualify if:

• Concurrent enrollment in another clinical study, unless it is an observational (non-interventional) clinical study or if the participant is in the follow-up period of an interventional study
• Participation in another clinical study with an investigational product during the last 4 weeks prior to enrollment on this study
• Prior randomization or treatment in a previous durvalumab clinical study regardless of treatment arm assignment
• Mixed small cell and non-small cell lung cancer histology
• Participants who receive sequential chemoradiation therapy for locally advanced NSCLC
• Participants with locally advanced NSCLC who have progressed whilst definitive platinum based, concurrent chemoradiation therapy
• Receipt of any investigational drug within 4 weeks prior to the first dose of durvalumab; and in the case of monoclonal antibodies (not immunotherapy) 6 weeks prior to the first dose of durvalumab
• Participants who have received prior anti-programmed death (PD)-1, anti- programmed death ligand (PD-L)1 or anti- cytotoxic T-lymphocyte-associated protein (CTLA)-4
• Participants who have received prior immunotherapy
• Receipt of live attenuated vaccine within 30 days prior to the first dose of investigational product (IP). Note: Participants, if enrolled, should not receive live vaccine whilst receiving durvalumab and up to 30 days after the last dose of IP
• Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab
• Any grade pneumonitis from prior chemoradiation therapy
• Active infection
• Recent major surgery within 28 days prior to the first dose of study therapy
• Active or prior documented autoimmune or inflammatory disorders
• +9 more criteria