TILs for Treatment of Metastatic or Recurrent Cervical Cancer

NCT04674488 | Unknown Early Phase 1

• 1 other identifier: OriginCell
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Prospective, single center, single-arm, open label, interventional study evaluating adoptive cell therapy (ACT) with autologous tumor infiltrating lymphocytes (TIL) infusion followed by IL-2 after a non-myeloablative (NMA) lymphodepletion preparative regimen for the treatment of patients with recurrent, metastatic cervical carcinoma.

Conditions

TILs, Metastatic or Recurrent Cervical Cancer

Outcome Measures

Primary Outcomes (1)

• dose limited toxicity, DLT

  Safety and tolerability of TILs, as determined by the rate of Dose Limiting Toxicities (DLTs)

  28 days

Secondary Outcomes (5)

• Objective Response Rate, ORR

  three months

• Duration of Response, DOR

  two years

• Progression-Free Survival, PFS

  two years

• overall survival, OS

  two years

• Disease Control Rate, DCR

  two years

Study Arms (1)

TILs intervention

EXPERIMENTAL

Biological: TILs

Interventions

TILs BIOLOGICAL

a single center, single-arm, open label, interventional study

TILs intervention

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18-70 years old;
• ECOG (Eastern Cooperative Oncology Group) score is 0 or 1;
• The case is diagnosed as cervical squamous cell carcinoma, adenosquamous carcinoma or cervical adenocarcinoma;
• Patients who have metastasized or relapsed after initial treatment (surgery, chemotherapy or radiotherapy);
• HPV (Human Papillomavirus)-DNA test shows HPV16 positive and/or HPV18 positive;
• At least one measurable target lesion defined by RECIST v1.1 (Response Evaluation Criteria in Solid Tumours);
• The subject must have a lesion with a diameter of more than 10 mm and a volume of 1.5 cm3 or more (or a collection of resected lesions greater than or equal to 1.5 cm3). TILs can be separated after resection or malignant effusion;
• Routine blood testing reaches the following indicators: neutrophils ≥ 1.5×10\^9/L, PLT ≥60×10\^9/L, Hb ≥9.0 g/dL, LY ≥0.4×10\^9/L;
• Liver and kidney function: ALT (Alanine Aminotransferase, alanine aminotransferase) or AST (Aspartate Aminotransferase, aspartate aminotransferase) index \<2.5 times the normal value; creatinine clearance rate\>50 ml/min; total bilirubin \<1.5 times the normal value, Prothrombin time prolonged ≤ 4 s;
• The treatment methods for malignant tumors, including radiotherapy, chemotherapy and biological agents (including granulocyte colony stimulating factor G-CSF, targeted drug therapy, etc.), must be stopped 28 days before the TILs are obtained;
• Subjects with reproductive potential must be willing to implement the approved high-efficiency contraceptive method with informed consent and continue to implement it within 1 year after the completion of the clinical trial;
• The subject is able to adhere to the research visit plan and other protocol requirements.

You may not qualify if:

• Uncontrolled active systemic infection; patients with active viral hepatitis;
• Confirmed HIV infection;
• The electrocardiogram indicates myocardial ischemia; the left ventricular ejection fraction on ultrasonography of subjects over 40 years old is less than 45%;
• Pulmonary function test (spirometry) proves that forced expiratory volume (FEV) 1\<65% predicted or forced vital capacity (FVC)\<65% predicted;
• Patients with a history of COPD (Chronic Obstructive Pulmonary Disease), asthma, or other chronic lung diseases with significant symptoms;
• The subject received systemic steroids equivalent to \>15 mg/day of prednisone 2 weeks before sampling, except for inhaled steroids;
• The patient has hereditary or acquired coagulopathy;
• Medical history of organ or hematopoietic stem cell transplantation;
• Patients who are pregnant or breastfeeding;
• Those who suffer from serious neurological, mental or endocrine diseases, or those who have serious mental diseases that will hinder full informed consent;
• The medical history of primary immunodeficiency, past immune system diseases includes autoimmune diseases that are active, or previously known or suspected to exist autoimmune diseases. Except for side effects of checkpoint inhibitors, vitiligo, psoriasis, type 1 diabetes, remission of childhood asthma, and remission of atopic side effects.
• Suffered from other uncured malignant tumors in the past 5 years or at the same time, except skin basal cell carcinoma and thyroid cancer.
• There are central nervous system metastases and central nervous system diseases with clinical significance;
• Live vaccine was vaccinated 30 days before cell reinfusion;
• Patients with a previous history of cell therapy within one year;

Sponsors & Collaborators

• Shanghai OriginCell Therapeutics Co., Ltd.: lead
• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine: collaborator

Study Sites (1)

Shanghai general hospital

Shanghai, Shanghai Municipality, 200080, China

RECRUITING

MeSH Terms

Conditions

Neoplasm Metastasis; Uterine Cervical Neoplasms

Condition Hierarchy (Ancestors)

Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 13, 2020
• First Posted: December 19, 2020
• Study Start: December 9, 2020
• Primary Completion: November 9, 2022
• Study Completion: November 9, 2024
• Last Updated: December 19, 2020

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)