Absolute Quantification in Bone Scintigraphy

NCT04671238 | Completed

• 1 other identifier: 2020PI241
• Study Type: observational
• Target: 21
• Locations: 1 country
• Sites: 3

Brief Summary

While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical interest remains to be demonstrated. Recent studies carried out on bone scan recordings show the potential interest of quantification indexes such as SUV (Standard Uptake Value).

Conditions

Scintigraphy Quantification

Keywords

bone scintigraphy; absolute quantification; Standard Uptake Value

Outcome Measures

Primary Outcomes (1)

• To validate the absolute bone scan quantification in a retrospectively selected patient population

  Analysis of SUV variation on at least 2 bone scans: Variation of the SUV over time on scans of patients with spinal fractures

  After 1 year

Secondary Outcomes (3)

• To calibrate the tomographic images from the gamma camera

  1 day

• To evaluate the attenuation correction on phantoms of different density

  1 day

• To evaluate absolute quantification on phantoms

  1 day

Study Arms (1)

Patient for SPECT/CT scan

Patients referred for SPECT/CT scan of the spine as part of a vertebroplasty workup and selected retrospectively.

Device: SPECT CT

Interventions

SPECT CT DEVICE

SPECT/CT scan of the spine as part of a vertebroplasty

Patient for SPECT/CT scan

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred for SPECT/CT scan of the spine as part of a vertebroplasty workup and selected retrospectively.

You may qualify if:

• Patients with recent vertebral fractures:
• who have had at least two SPECT/CT scan scans of the spine as part of a pre-vertebroplasty check-up,
• for which fracture dates were known.

You may not qualify if:

• Minor person
• Person opposing the use of their data (Posters in waiting rooms explaining that the patient must object if they do not wish their data to be used)

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (3)

CHU de Nancy - Hôpital Brabois

Vandœuvre-lès-Nancy, 54500, France

Location

Chru Nancy

Vandœuvre-lès-Nancy, 54511, France

Location

CHRU of Nancy

Vandœuvre-lès-Nancy, 54511, France

Location

MeSH Terms

Interventions

Single Photon Emission Computed Tomography Computed Tomography

Intervention Hierarchy (Ancestors)

Tomography, Emission-Computed, Single-Photon; Tomography, Emission-Computed; Image Interpretation, Computer-Assisted; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography, X-Ray Computed; Multimodal Imaging; Radiographic Image Enhancement; Image Enhancement; Photography; Radiography; Tomography, X-Ray; Radionuclide Imaging; Tomography; Diagnostic Techniques, Radioisotope

Study Officials

• BALHOUL Achraf, MD

  CHRU of Nancy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Study director

Study Record Dates

• First Submitted: November 13, 2020
• First Posted: December 17, 2020
• Study Start: January 1, 2020
• Primary Completion: November 1, 2020
• Study Completion: February 1, 2021
• Last Updated: September 13, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (3)