Efficiency of the Quadratus Lumborum Block for Post-operative Analgesia in Abdominoplasty Surgery

NCT04670224 | Active Not Recruiting

• 1 other identifier: PI2020_843_0094
• Study Type: interventional
• Target: 286
• Locations: 1 country
• Sites: 1

Brief Summary

Abdominoplasty is a common surgical procedure in plastic surgery which causes postoperative pain and may delay patients' recovery. Surgery is potentially associated with a number of postoperative complications, whether cardiovascular, respiratory, infectious, thromboembolic, or digestive … Although they do not inevitably lead to a life-threatening prognosis, in many cases these complications delay post-operative recovery. Defined in the 1990s by Professor Henry Kehlet's Danish team, rapid rehabilitation after planned surgery is an approach to overall patient care that aims to rapidly restore previous physical and mental capacities and thus significantly reduce mortality and morbidity. Pain management is at the heart of this program and local anesthesia techniques are at the heart of early rehabilitation programs. Described for just over a decade, Quadratus Lumborum Block (QLB) have shown their effectiveness for analgesia in abdominal, or orthopedic, or obstetrical surgery. Considering the anatomical territory concerned, this locoregional anesthesia technique seems to be very interesting in abdominoplasty to allow early rehabilitation of the patient.

Conditions

Quadratus Lumborum Block; Abdominoplasty; Analgesia; Locoregional Anesthesia

Keywords

Quadratus lumborum block; Abdominoplasty; Analgesia; Locoregional Anesthesia

Outcome Measures

Primary Outcomes (1)

• Variation from baseline of morphine consumption

  24 hours after surgery

Secondary Outcomes (3)

• Variation from baseline of morphine consumption

  1 hour after surgery

• Variation from baseline of morphine consumption

  2 hours after surgery

• Variation from baseline of morphine consumption

  48 hours after surgery

Study Arms (2)

QLB technique

EXPERIMENTAL

Other: QLB anesthesia

Intravenous anesthesia without QLB

ACTIVE COMPARATOR

Other: Intravenous anesthesia without QLB

Interventions

QLB anesthesia OTHER

The QLB is a bilateral locoregional anesthesia technique, performed after surgery, under general anesthesia and in right and then left lateral decubitus.

QLB technique

Intravenous anesthesia without QLB OTHER

only intravenous anesthesia

Intravenous anesthesia without QLB

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients admitted for programmed dermo-lipectomy surgery with or without associated liposuction.

You may not qualify if:

• Pregnant woman
• Patient under 18 years of age
• Subject under guardianship or curators
• Patient allergic to local anesthetics
• Infection at the puncture sites
• Patient on morphine analgesic over the long term
• Patient on antidepressants for neuropathic pain.

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

BAR

Amiens, 80054, France

Location

MeSH Terms

Conditions

Agnosia

Interventions

Anesthesia, Intravenous

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 1, 2020
• First Posted: December 17, 2020
• Study Start: March 16, 2021
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: May 29, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)