NCT04662450

Brief Summary

The primary objective of this study is to examine the effects of Attentional Bias Modification (ABM) on the labor pain in parturients. One-third of the participants will undergo ABM training away from affective pain stimuli. One-third of the participants will undergo ABM training away from sensory pain stimuli. The rest of participants will be the control group.

Trial Health

45
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
6mo left

Started Sep 2024

Typical duration for not_applicable

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress77%
Sep 2024Dec 2026

First Submitted

Initial submission to the registry

July 31, 2018

Completed
2.4 years until next milestone

First Posted

Study publicly available on registry

December 10, 2020

Completed
3.7 years until next milestone

Study Start

First participant enrolled

September 1, 2024

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

May 13, 2024

Status Verified

May 1, 2024

Enrollment Period

2 years

First QC Date

July 31, 2018

Last Update Submit

May 9, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Effects of Attentional Bias Modification (ABM) on labor pain

    Change in pain threshold and labor pain as measured by Fear of Pain Questionnaire (FPQ), Brief Pain Inventory (BPI) and McGill Pain Questionnaire (MPQ) before and after the ABM training.

    4 weeks (starting from 36-week gestation)

Study Arms (3)

Affective pain stimuli group

EXPERIMENTAL

affective/neutral word pairs

Behavioral: ABM affective pain stimuli

Sensory pain stimuli group

EXPERIMENTAL

sensory/neutral word pairs

Behavioral: ABM sensory pain stimuli

Control group

PLACEBO COMPARATOR

affective/neutral and sensory/neutral word pairs

Behavioral: Placebo

Interventions

Patients undergo ABM training to shift attention away from affective pain stimuli

Affective pain stimuli group

Patients undergo ABM training to shift attention away from sensory pain stimuli

Sensory pain stimuli group
PlaceboBEHAVIORAL

Patients undergo ABM training to receive affective/neutral and sensory/neutral word pairs

Control group

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsParturients
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Parturients who are at 36 weeks gestation (at time of starting the study)

You may not qualify if:

  • Any patient who refuses
  • Patients with impaired decision-making capacity
  • Patients who are blind or extremely visually impaired
  • Patients who cannot understand or read English

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Todd J, Sharpe L, Colagiuri B. Attentional bias modification and pain: The role of sensory and affective stimuli. Behav Res Ther. 2016 Aug;83:53-61. doi: 10.1016/j.brat.2016.06.002. Epub 2016 Jun 15.

    PMID: 27327608BACKGROUND
  • Schoth DE, Georgallis T, Liossi C. Attentional bias modification in people with chronic pain: a proof of concept study. Cogn Behav Ther. 2013;42(3):233-43. doi: 10.1080/16506073.2013.777105. Epub 2013 Jun 4.

  • Duschek S, Werner NS, Limbert N, Winkelmann A, Montoya P. Attentional bias toward negative information in patients with fibromyalgia syndrome. Pain Med. 2014 Apr;15(4):603-12. doi: 10.1111/pme.12360. Epub 2014 Jan 21.

MeSH Terms

Conditions

Labor Pain

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Jie Zhou, MD, MS, MBA

    Harvard Medical School (HMS and HSDM)

    PRINCIPAL INVESTIGATOR
0

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

July 31, 2018

First Posted

December 10, 2020

Study Start

September 1, 2024

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

May 13, 2024

Record last verified: 2024-05

Data Sharing

IPD Sharing
Will not share