A Comparison of the TIMI, GRACE, HEART and HEARTSIL Scores

NCT04661722 | Unknown

• 1 other identifier: Konya city hospital
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Chest pain is one of the most common reasons for emergency admission. Chest pain can be caused by many cardiac and noncardiac causes. Acute Coronary Syndrome (ACS) is one of the most im-portant of these etiologies. ACS has a high mortality rate, but with early diagnosis and related inter-ventions, a high rate of prognosis can be improved. Therefore, early recognition of AKS is impor-tant. However, the challenge in emergency services is not only to identify patients with high risk for ACS. Early detection of low-risk patients is also important for emergency room management. These patients should be discharged quickly with minimal examination and treatment. The follow-up of these patients with the acceptance of ACS brings along unnecessary examinations and treatments. This leads to an increase in healthcare costs and an increase in crowd in emergency services and hospitals. Evaluation of chest pain in the emergency room and early detection of life-threatening conditions such as ACS present many difficulties for clinicians. For this reason, clinicians use some scoring systems that determine the risk stratification of patients and the probability of having acute coronary syndrome. Heart score is one of the scores developed for this purpose. However vital signs are not included in calculating the heart score. Therefore, the investigators considered to include the shock index calcula-ted by systolic blood pressure and pulse in this scoring system. In addition, the investigators have included a very valuable biochemical parameter such as lactate that predicts mortality in many diseases in this scoring system. The investigators named this scoring system HEARTSIL. The investigators aim to compare the diagnostic performance of this score with the diagnostic performance of other scoring systems.

Conditions

Chest Pain

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiac Events (MACE) at 30 days

  The primary outcome is MACE at 30 days. MACE is a composite outcome of cardiac death, acute myocardial infarction, and coronary revascularization.

  30 days after presentation.

Secondary Outcomes (1)

• Major Adverse Cardiac Events (MACE) at 3 days

  3 days after presentation.

Interventions

No intervention OTHER

No intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with chest pain.

You may qualify if:

• Patient presenting to the emergency department with chest pain

You may not qualify if:

• ST elevation myocardial infarction,
• Pneumonia, pneumothorax, pulmonary embolism and esophageal rupture
• Patients under 18 years of age
• Pregnant patients
• Patients who do not want to be included in the study

Sponsors & Collaborators

• Konya Meram State Hospital: lead

Study Sites (1)

Konya City Hospital

Konya, 42020, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Chest Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Nazire B Akilli, Assoc Prof

  Konya City Hospital

  PRINCIPAL INVESTIGATOR

• Pervin Sagdıc, MD

  Konya City Hospital

  STUDY CHAIR

• Turgut Uygun, MD

  Konya City Hospital

  STUDY CHAIR

• Ramazan Koylu, Assoc Prof

  Konya City Hospital

  STUDY CHAIR

Central Study Contacts

Nazire Belgin Akilli, assoc prof

CONTACT

+90 5055377520; drbelginakilli@hotmail.com

Pervin Sagdıc, MD

CONTACT

prvnsgdc@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: December 3, 2020
• First Posted: December 10, 2020
• Study Start: February 5, 2021
• Primary Completion: June 14, 2021
• Study Completion: July 14, 2021
• Last Updated: April 26, 2021

Record last verified: 2020-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)