Thyroid Function Tests and Status of Thyroid Autoantibodies in Covid-19 Patients
Thyroid Function Tests and the Status of Thyroid Autoantibodies in Hospitalized Covid-19 Patients and Their Relationship With White Blood Cells, Neutrophil / Lymphocyte Ratio, c Reactive Protein, Fibrinogen, Procalcitonin, Ferritin and D-dimer
1 other identifier
observational
20
1 country
1
Brief Summary
COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation through cytokines in various organs of the body, especially the lungs. This cytokine-mediated widespread inflammation can also affect the thyroid gland, causing thyroiditis and impaired thyroid functions. The researchers evaluated thyroid function tests and thyroid autoantibodies in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known thyroid disease. The researchers examined the relationship of thyroid hormones and thyroid autoantibodies to COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer stages in these patients. Researchers compared changes in thyroid hormones and autoantibodies in people without COVID-19 infection and without thyroid disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 5, 2020
CompletedFirst Submitted
Initial submission to the registry
December 7, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 7, 2020
CompletedFirst Posted
Study publicly available on registry
December 9, 2020
CompletedJanuary 26, 2021
January 1, 2021
3 months
December 7, 2020
January 25, 2021
Conditions
Outcome Measures
Primary Outcomes (12)
Comparison of thyroid stimulating hormone (TSH) between groups
In the study, serum TSH results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
90 days
Comparison of free triiodothyronine (fT3) between groups
In the study, serum fT3 results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
90 days
Comparison of free thyroxine (fT4) between groups
In the study, serum fT4 results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
90 days
Comparison of anti-thyroid peroxidase (Anti-TPO) between groups
In the study, serum anti-TPO results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
90 days
Comparison of anti-thyroglobulin (Anti-Tg) between groups
In the study, serum anti-Tg results of the Covid patient group and non-Covid control groups were recorded and compared statistically.
90 days
White blood cells (WBC) results of Covid 19 patient group
In the study, serum WBC results were recorded in Covid 19 patient groups.
90 days
Neutrophil / lymphocyte ratio (N/LO) results of Covid 19 patient group
In the study, serum N/LO results were recorded in Covid 19 patient groups.
90 days
C-reactive protein (CRP) results of Covid 19 patient group
In the study, serum CRP results were recorded in Covid 19 patient groups.
90 days
Fibrinogen results of Covid 19 patient group
In the study, serum fibrinogen results were recorded in Covid 19 patient groups.
90 days
Procalcitonin results of Covid 19 patient group
In the study, serum procalcitonin results were recorded in Covid 19 patient groups.
90 days
Ferritin results of Covid 19 patient group
In the study, serum ferritin results were recorded in Covid 19 patient groups.
90 days
D-dimer results of Covid 19 patient group
In the study, serum D-dimer results were recorded in Covid 19 patient groups.
90 days
Study Arms (2)
Covid Disease Patient Group
Researchers evaluated serum thyrotropin, free triiodothyronine, free thyroxine hormones, thyroid peroxidase antibodies and anti-thyroglobulin antibodies in patients hospitalized for COVID-19 infection. The researchers evaluated the results of white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, D-dimer in Covid-9 patients.
Covid-Free Control Group
Researchers evaluated the results of serum thyrotropin, free triiodothyronine, free thyroxine hormones, thyroid peroxidase antibodies and anti-thyroglobulin antibodies, white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, D-dimer in the non-patient control group.
Interventions
For the measurement of blood tests, 10 ml of blood samples were taken from the right forearm veins with a syringe.
Eligibility Criteria
The results of screening thyroid blood tests of healthy people without thyroid disease will be compared with the records of the COVID 19 patient group who were hospitalized and treated with no known thyroid disease.
You may qualify if:
- To accept research.
- Being over the age of 18.
- COVID 19 test results to be positive.
- Not taking thyroid disease medication before.
- Receiving inpatient treatment in the COVID service in the hospital.
You may not qualify if:
- Not accepting research.
- Be under the age of 18.
- Negative COVID 19 test results for patients.
- COVID patients treated as outpatient.
- Thyroid disease in the healthy control group.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Sabahattin Destek
Fatih, Istanbul, 34093, Turkey (Türkiye)
Related Publications (4)
Brancatella A, Ricci D, Viola N, Sgro D, Santini F, Latrofa F. Subacute Thyroiditis After Sars-COV-2 Infection. J Clin Endocrinol Metab. 2020 Jul 1;105(7):dgaa276. doi: 10.1210/clinem/dgaa276.
PMID: 32436948BACKGROUNDCaron P. Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management. Ann Endocrinol (Paris). 2020 Oct;81(5):507-510. doi: 10.1016/j.ando.2020.09.001. Epub 2020 Sep 18.
PMID: 32950466BACKGROUNDMattar SAM, Koh SJQ, Rama Chandran S, Cherng BPZ. Subacute thyroiditis associated with COVID-19. BMJ Case Rep. 2020 Aug 25;13(8):e237336. doi: 10.1136/bcr-2020-237336.
PMID: 32843467BACKGROUNDvan Gerwen M, Alsen M, Little C, Barlow J, Naymagon L, Tremblay D, Sinclair CF, Genden E. Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study. Front Endocrinol (Lausanne). 2020 Aug 18;11:565. doi: 10.3389/fendo.2020.00565. eCollection 2020.
PMID: 33013686RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
December 7, 2020
First Posted
December 9, 2020
Study Start
September 1, 2020
Primary Completion
December 5, 2020
Study Completion
December 7, 2020
Last Updated
January 26, 2021
Record last verified: 2021-01