Incidence of Complications Associated With Anesthesia in Obesity Parturient Undergoing Cesarean Delivery

NCT04657692 | Completed

• 2 other identifiers: 873/2562 (EC2)Si 125/2020
• Study Type: observational
• Target: 527
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of obesity parturient has been increasing worldwide. There was a report revealing one third of pregnant women in United state considered obesity. Obesity is associated with increased in maternal and neonatal complications. Also, there was an increasing in the rate of cesarean delivery. Anesthetic management of the obese parturient is differ from non-obese parturients. There were higher risk of difficult intubation, failed intubation, pulmonary aspiration and difficult regional anesthesia such as spinal anesthesia or epidural catheter placement comparing with non-obese parturient. The aim of the study is to report complication associated with anesthesia in obese patients undergoing cesarean delivery in Single University hospital, Bangkok, THAILAND.

Conditions

Cesarean Section Complications; Anesthesia Complication; Obesity, Morbid

Keywords

anesthetic complications; maternal outcomes; neonatal outcomes; cesarean section; obesity

Outcome Measures

Primary Outcomes (1)

• Incidence of complications

  Incidence of maternal complications associated with anesthesia

  intraoperative period to 24 hours postoperative

Secondary Outcomes (2)

• Incidence of obstetric-related complications

  intraoperative period to 24 hours postoperative

• Neonatal outcomes

  Neonate apgar score at 1-min and 5 min

Interventions

Anesthesia; general or regional PROCEDURE

General anesthesia: general anesthesia with endotracheal tube Regional anesthesia: spinal anesthesia, epidural anesthesia, combined spinal epidural anesthesia

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Obese pregnant women whose body mass index (BMI\>,= 40 kg/m2) underwent cesarean delivery

You may qualify if:

• Pregnant women BMI\>,= 40 kg/m2 underwent cesarean delivery

You may not qualify if:

• Patients with gestational age \<,= 24 weeks
• Patients with death fetus in Utero
• Multiple gestation
• Patients with intrapelvic cavity pathology eg. myoma uteri
• Patients with abnormal placentation
• Patients with polyhydramnios

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Patchareya Nivatpumin

Bangkok, 10700, Thailand

Location

Related Publications (1)

• Nivatpumin P, Lertbunnaphong T, Maneewan S, Vittayaprechapon N. Comparison of perioperative outcomes and anesthetic-related complications of morbidly obese and super-obese parturients delivering by cesarean section. Ann Med. 2023 Dec;55(1):1037-1046. doi: 10.1080/07853890.2023.2187877.

  PMID: 36947155 RESULT

MeSH Terms

Conditions

Obesity, Morbid; Obesity

Interventions

Anesthesia; Amino Acid Motifs

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anesthesia and Analgesia; Protein Structural Elements; Protein Conformation; Molecular Conformation; Molecular Structure; Biochemical Phenomena; Chemical Phenomena; Protein Structure, Secondary

Study Officials

• Patchareya Nivatpumin, M.D.

  Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 1, 2020
• First Posted: December 8, 2020
• Study Start: December 29, 2020
• Primary Completion: October 31, 2021
• Study Completion: December 31, 2021
• Last Updated: April 11, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)