NCT04656483

Brief Summary

Infants with Neurodevelopmental Disabilities (ND) show emotional, cognitive and socio-interactive dysregulation dramatically impacting on caregiving behavior. Early family-centered rehabilitation interventions are effective in promoting better infant outcomes and in optimizing healthcare systems economic return in the long-term. The Video Feedback intervention (VFI) is effective in promoting sensitive parenting and supporting infants' development. In the light of limited resources of the healthcare systems, technological advance in telemedicine may facilitate the delivery of VFI to a greater number of families of infants with ND. Consistently, the Supporting Parenting at Home: Empowering Rehabilitation through Engagement (SPHERE) project is a randomized controlled trial (RCT) aiming at assessing effectiveness and efficacy of an early family centered VFI parenting support delivered through videoconferencing on dyads with infants with ND.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
168

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2021

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 30, 2020

Completed
7 days until next milestone

First Posted

Study publicly available on registry

December 7, 2020

Completed
1 month until next milestone

Study Start

First participant enrolled

January 7, 2021

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
Last Updated

April 6, 2021

Status Verified

April 1, 2021

Enrollment Period

2.5 years

First QC Date

November 30, 2020

Last Update Submit

April 2, 2021

Conditions

Keywords

early family-centered interventiontelemedicinevideo feedbackparentingtelerehabilitationdisabilitypsychomotor delay

Outcome Measures

Primary Outcomes (1)

  • Maternal sensitivity

    The maternal sensitivity will be coded through the Global Rating Scales (Murray, Fiori-Cowley, Hooper, \& Cooper, 1996). The score will range from 1 (low) to 5 (high).

    Immediate post-intervention (6 weeks after the intervention started)

Secondary Outcomes (3)

  • Infant emotional stress reactivity

    Immediate post-intervention (6 weeks after the intervention started)

  • Maternal sensitivity

    Follow-up (6 months adfter the intervention ended)

  • Infant emotional stress reactivity

    Follow-up (6 months adfter the intervention ended)

Other Outcomes (8)

  • Maternal Stress

    Immediate post-intervention (6 weeks after the intervention started)

  • Maternal Stress

    Follow-up (6 months adfter the intervention ended)

  • Maternal depression

    Immediate post-intervention (6 weeks after the intervention started)

  • +5 more other outcomes

Study Arms (2)

Telemedicine Video Feedback Arm

EXPERIMENTAL

Mother-child dyads will take part into a 6 video-conference sessions of Video Feedback (vVF). The vVF will be standardized according to previously published RCTs. Specifically, the 6 vVFI sessions will be organized in two subsequent phases: 4 sessions based on sharing the focus on different relational themes, and 2 sessions of interactive integration. In more specific terms, during the first set of 4 sessions the psychologist will review with mothers' segments of the videotapes obtained during the baseline assessment and will focus on four different relational themes: responsiveness, physical stimulation, teaching, and parenting experience. During the interactive integration session, the insights developed from the first 4 videoconferences will be applied to the real-time interaction between the parent and his/her infant under the guidance of the psychologist.

Other: Telemedicine Video Feedback Intervention

Psychoeducational booklet arm

ACTIVE COMPARATOR

Mothers assigned to condition B will receive an informative booklet addressing the same themes discussed in the experimental intervention (i.e., responsiveness, physical stimulation, teaching, and parenting experience), but not tailored on their own infant or specific parenting challenges.

Other: Psychoeducational Booklet Intervention

Interventions

Mother-child dyads will take part into a 6 video-conference sessions of Video Feedback (vVF). The vVF will be standardized according to previously published RCTs. Specifically, the 6 vVFI sessions will be organized in two subsequent phases: 4 sessions based on sharing the focus on different relational themes, and 2 sessions of interactive integration. In more specific terms, during the first set of 4 sessions the psychologist will review with mothers' segments of the videotapes obtained during the baseline assessment and will focus on four different relational themes: responsiveness, physical stimulation, teaching, and parenting experience. During the interactive integration session, the insights developed from the first 4 videoconferences will be applied to the real-time interaction between the parent and his/her infant under the guidance of the psychologist.

Telemedicine Video Feedback Arm

Mothers of this condition will receive an informative booklet addressing the same themes included in the experimental intervention (responsiveness, physical stimulation, teaching, and parenting experience), but not tailored on their own infant status.

Psychoeducational booklet arm

Eligibility Criteria

Age1 Month - 18 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • infants' (corrected) age between 1 and 18 months;
  • presence of developmental risk or diagnosis of ND as defined by standardized clinical criteria;
  • parental age greater than 18 years;
  • parental mastery of Italian language;
  • parents living together with the infant.

You may not qualify if:

  • Twins;
  • Infant's life-threatening conditions;
  • Maternal full-blown documented psychiatric disorders.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mondino Foundation

Pavia, PV, 27100, Italy

RECRUITING

Related Publications (1)

  • Grumi S, Borgatti R, Provenzi L. Supporting Parenting at Home-Empowering Rehabilitation through Engagement (SPHERE): study protocol for a randomised control trial. BMJ Open. 2021 Dec 14;11(12):e051817. doi: 10.1136/bmjopen-2021-051817.

MeSH Terms

Conditions

Neurodevelopmental DisordersLearning Disabilities

Condition Hierarchy (Ancestors)

Mental DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Serena Grumi, PhD

    IRCCS Mondino Foundation, Pavia, Italy

    PRINCIPAL INVESTIGATOR
  • Livio Provenzi, PhD

    IRCCS Mondino Foundation, Pavia, Italy

    STUDY CHAIR

Central Study Contacts

Livio Provenzi, PhD

CONTACT

Serena Grumi, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 30, 2020

First Posted

December 7, 2020

Study Start

January 7, 2021

Primary Completion

June 30, 2023

Study Completion

December 31, 2023

Last Updated

April 6, 2021

Record last verified: 2021-04

Data Sharing

IPD Sharing
Will not share

Locations