Assessment of Left Ventricular Diastolic Function in Patients With Atrial Fibrillation
DIAAF
1 other identifier
observational
200
1 country
1
Brief Summary
This study is a single-center, prospective cohort study to investigate non-invasive method to assess left ventricular diastolic function using echocardiography. Patients with AF who are referred radiofrequency catheter ablation (RFA) will be included prospectively. Transthoracic echocardiography will be performed during, immediately before RFA and with no cardiovascular medication taken between the exams so that the loading conditions during catheterization and echocardiography are as similar as possible. We will validate previously proposed echocardiographic parameters and creat an algorithm to identify the relationship between echocardiographic parameters of diastolic function and invasively measured LA pressure in patients with atrial fibrillation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2020
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 25, 2020
CompletedFirst Submitted
Initial submission to the registry
November 26, 2020
CompletedFirst Posted
Study publicly available on registry
December 4, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedMay 10, 2022
May 1, 2022
3 years
November 26, 2020
May 9, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Association between mean left atrial pressure and echocardiographic parameters
Correlation between echocardiographic parameters or algorithm to estimate invasively measured left atrial pressure. Echocardiographic parameters: E/A ratio, E velocity, e' velocity, E/e', IVRT. LV strain, RV strain,, LA strain, Vp, E/Vp, LA volume index, TV V max, and Peak acceleration rate of mitral E velocity
up to 12 weeks after collecting all data
Eligibility Criteria
Patients who scheduled to perform radiofrequency catheter ablation for atrial fibrillation
You may qualify if:
- Adult ≥ 19 year-old
- Patients who scheduled to perform radiofrequency catheter ablation for atrial fibrillation
- Patients who had paroxysmal, persistent, or chronic AF
- Patients provided with the written, informed consent to participate in this study
You may not qualify if:
- Patients with prosthetic valve
- Life expectancy \< 12 months
- Subject who the investigator deems inappropriate to participate in this study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
Seoul, South Korea
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jong-Won Ha
Severance Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 26, 2020
First Posted
December 4, 2020
Study Start
November 25, 2020
Primary Completion
December 1, 2023
Study Completion
December 1, 2023
Last Updated
May 10, 2022
Record last verified: 2022-05
Data Sharing
- IPD Sharing
- Will not share