Total Posterior-circulation Infarct Volume in Basilar Artery Stroke

NCT04650022 | Completed

• 1 other identifier: RECHMPL20_0636
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Preprocedural predictors of outcome in patients with acute basilar artery occlusion (ABAO) who underwent endovascular treatment (EVT) remain controversial. The Investigators aimed to analyse, in patients with ABAO treated by EVT, if pre-EVT DWI total posterior-circulation infarct volume (TPIV) was a predictor of 90-days outcomes

Conditions

Ischemic Stroke

Keywords

MRI; Posterior fossa; Thrombectomy; Stroke

Outcome Measures

Primary Outcomes (1)

• measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability

  90-day functional outcome A favorable outcome was defined as a 90-day mRS≤2

  90 day

Secondary Outcomes (1)

• Mortality rate

  90 day

Study Arms (1)

TPCIV-ABAO

TPCIV-ABAO

Device: Mechanical thrombectomy

Interventions

Mechanical thrombectomy DEVICE

Stent retriever for treatment of cerebral arterial occlusions

TPCIV-ABAO

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients \>18 years, referred to our hospital, from January 2011 to October 2018, presenting acute basilar artery occlusion (ABAO) confirmed by magnetic resonance imaging treated by endovascular thrombectomy, with or without intravenous thrombolysis.

You may qualify if:

• patient with a clinical diagnosis of acute stroke in the posterior-circulation within 24 hours from symptom onset;
• patient with a pertinent clinical deficit following physician evaluation (no NIHSS limit);
• acute basilar ischemia assessed on MRI matching clinical symptoms and including DWI;
• ABAO confirmed by intra-arterial arteriography and treated using mechanical thrombectomy.

You may not qualify if:

• Patients were excluded if they were ineligible for an MRI or ineligible for MT for the following reasons:
• prestroke modified Rankin Scale (mRS) score of \>2;
• life expectancy \<3 months;
• brainstem ischemia on DWI involving more than 80% of the area in axial view

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Ischemic Stroke; Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Isabelle Mourand, MD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 24, 2020
• First Posted: December 2, 2020
• Study Start: January 30, 2011
• Primary Completion: October 1, 2018
• Study Completion: January 1, 2019
• Last Updated: December 8, 2020

Record last verified: 2020-11

Locations

FR (1)