Higher Levothyroxine Requirements After Right-side Hemithyroidectomy
Higher Post-operative Levothyroxine Substitution Dose Needed in Right Compared to Left Lobe Hemithyroidectomy - a Retrospective Cohort Study
1 other identifier
observational
459
1 country
1
Brief Summary
459 adult patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018 were identified and investigated in this retrospective study. The aim of this study was to investigate whether patients post right side hemithyroidectomy require a higher mean levothyroxine dosage than patients after left lobe hemithyroidectomy as the right thyroid lobe is bigger than the left lobe. Further, we aimed at developing a better post-surgery thyroid dosage prediction model.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 5, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 12, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 12, 2020
CompletedFirst Submitted
Initial submission to the registry
November 22, 2020
CompletedFirst Posted
Study publicly available on registry
December 1, 2020
CompletedDecember 1, 2020
November 1, 2020
1 month
November 22, 2020
November 28, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Levothyroxine dosage
dosage of levothyroxine needed post surgery, compared between left and right side hemithyroidectomy
within 3 to 12 months post surgery
Secondary Outcomes (1)
Hypothyroidism
within 3 to 12 months post surgery
Study Arms (2)
Left-side hemithyroidectomy
Patients who received a hemithyroidectomy of the left thyroid lobe since 1994
Right-side hemithyroidectomy
Patients who received a hemithyroidectomy of the right thyroid lobe since 1994
Interventions
We investigated patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018.
Eligibility Criteria
All patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018 were identified and investigated in this retrospective study.
You may qualify if:
- years
- Males and females
- St.p. hemithyroidectomy
You may not qualify if:
- Radiation therapy
- Pregnancy
- Previous thyroid surgery (e.g. nodule removal surgery)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical University of Vienna
Vienna, 1090, Austria
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lana Kosi-Trebotic
Medical University of Vienna
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
November 22, 2020
First Posted
December 1, 2020
Study Start
May 5, 2020
Primary Completion
June 12, 2020
Study Completion
June 12, 2020
Last Updated
December 1, 2020
Record last verified: 2020-11
Data Sharing
- IPD Sharing
- Will not share