NCT04643509

Brief Summary

Cardiac surgery is at high risk of low cardiac output syndrome after procedure. Monitoring cardiac function, and especially cardiac output, is important to identify cardiovascular dysfunction and to introduce and adjust optimal therapies. Invasive monitor such as pulmonary arterial catheter or transpulmonary thermodilution provide precise measurements but need an invasive access to arterial and central venous route, with possible complications. Cardiographic bioimpedencemetry (Niccomo device, Imedex Corp) allows a non invasive measurement of cardiac output and some other parameters of cardiovascular function. Nevertheless, the reliability of this device has been little studied after cardiac surgery.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Dec 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 19, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

November 25, 2020

Completed
23 days until next milestone

Study Start

First participant enrolled

December 18, 2020

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 18, 2022

Completed
5 days until next milestone

Study Completion

Last participant's last visit for all outcomes

December 23, 2022

Completed
Last Updated

December 24, 2020

Status Verified

November 1, 2020

Enrollment Period

2 years

First QC Date

November 19, 2020

Last Update Submit

December 22, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • agreement between cardiac outputs measured by Pulmonary Arterial Catheter (PAC) and Niccomo

    Cardiac outputs and systolic ejection volumes are measured at 10 different time-points and agreement between the 2 devices are explored

    48 hours

Secondary Outcomes (4)

  • Systolic Time Ratio

    48 hours

  • Pre-ejection Period

    48 hours

  • Velocity Index

    48 hours

  • Left Ventricular Ratio

    48 hours

Study Arms (1)

cardiac surgery

patients benefiting from pulmonary arterial catheter monitoring after cardiac surgery

Device: Niccomo

Interventions

NiccomoDEVICE

Niccomo monitoring added to pulmonary arterial catheter monitoring

cardiac surgery

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients bénéfiting from cardiac surgery and pulmonary arterial catheter at the discretion of the physician

You may qualify if:

  • age \> 18 y/o
  • Patients benefiting from cardiac surgery AND pulmonary arterial catheter monitoring

You may not qualify if:

  • Aortic regurgitation grade 3-4
  • Uncontrolled Hypertension (MAP \> 130 mmHg)
  • Circulatory or cardiac assistance
  • Active pacemaker

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rouen University Hospital

Rouen, 76000, France

RECRUITING

MeSH Terms

Conditions

Shock, CardiogenicCardiac Output, Low

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosisShockSigns and Symptoms

Central Study Contacts

Emmanuel Besnier, MD PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 19, 2020

First Posted

November 25, 2020

Study Start

December 18, 2020

Primary Completion

December 18, 2022

Study Completion

December 23, 2022

Last Updated

December 24, 2020

Record last verified: 2020-11

Locations