Study Stopped
Abandonment of the study project
Angiotensin-converting Enzyme 2 (ACE2) Expression in Tonsils and Adenoids
ACE2-AVG
Study of the Expression of Angiotensin-converting Enzyme 2 (ACE2), a Cell Membrane Receptor for SARS-CoV-2 and the TMPRSS2 Serine Protease in Tonsils and Adenoids of Children and Adults
1 other identifier
observational
N/A
1 country
9
Brief Summary
The objective of the research is to study the expression of the ACE 2 receptor and the TMPRSS2 serine protease in the tonsils and adenoids of children and adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jun 2021
9 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 19, 2020
CompletedFirst Posted
Study publicly available on registry
November 23, 2020
CompletedStudy Start
First participant enrolled
June 30, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedMarch 12, 2026
March 1, 2026
Same day
November 19, 2020
March 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Expression of ACE 2 receptor and TMPRSS2 serine protease
Measurement of expression of ACE 2 receptor and TMPRSS2 serine protease in tonsils and adenoids labeled by immunofluorescence.
9 months
Secondary Outcomes (1)
Location of ACE 2 receptor and TMPRSS2 serine protease
9 months
Study Arms (1)
Adenoidectomy / tonsillectomy
Children and adults, without SARS-CoV-2 infection, in whom an adenoidectomy and/or tonsillectomy is performed for their care in the centers of the study.
Interventions
Storage of operating waste of adenoidectomy / tonsillectomy
Eligibility Criteria
Children and adults, without SARS-CoV-2 infection, in whom an adenoidectomy and/or tonsillectomy is performed for their care in the centers of the study.
You may qualify if:
- Children and adults, without SARS-CoV-2 infection, in whom an adenoidectomy and/or tonsillectomy is performed for their care in the hospitals of Assistance Publique-Hôpitaux de Paris participating in the study.
- Holders of parental authority of minor patients and adult patients not opposed to participation in the study.
You may not qualify if:
- \- N/A
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (9)
Hôpital Mondor
Créteil, 94000, France
Hôpital Bicêtre
Le Kremlin-Bicêtre, 94270, France
Hôpital Lariboisière
Paris, 75010, France
Hôpital Armand Trousseau
Paris, 75012, France
Hôpital Pitié Salpêtrière
Paris, 75013, France
HEGP
Paris, 75015, France
Hôpital Necker-Enfants Malades
Paris, 75015, France
Hôpital Bichat
Paris, 75018, France
Hôpital Tenon
Paris, 75020, France
Biospecimen
Tonsils and adenoids preserved by cryopreservation and fixed with formalin.
Study Officials
- PRINCIPAL INVESTIGATOR
Romain Luscan, MD
Assistance Publique - Hôpitaux de Paris
- STUDY DIRECTOR
Pierre-Louis Tharaux, MD, PhD
Institut National de la Santé Et de la Recherche Médicale, France
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 19, 2020
First Posted
November 23, 2020
Study Start
June 30, 2021
Primary Completion
June 30, 2021
Study Completion
June 30, 2021
Last Updated
March 12, 2026
Record last verified: 2026-03
Data Sharing
- IPD Sharing
- Will not share