Retrospective Assessment of the Morphology of Acetabular Defects: A 3D Reconstruction Approach

NCT04638140 | Terminated DMC

• 1 other identifier: S61746
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we aim to develop a statistical shape model and use it to reconstruct the shape of acetabula with severe defects (Paprosky 3a-3b). This will allow us to visualise and assess the morphology of the missing bone. In future studies we will use the obtained results to improve the design of acetabular implants for revision surgery.

Conditions

Hip Arthrosis; Hip Injuries

Keywords

Hip revision surgery

Outcome Measures

Primary Outcomes (1)

• 3D morphology

  Compare the 3D morphology of acetabular defects (missing bone) with traditional 2D classifications using CT images of patients with various degrees of bone defects.

  2 years

Study Arms (2)

Healthy hip population

Hip defect population

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Trainings dataset for statistical shape model: * Bones with irregularities, such as fractures or osteophytes * Patients who received radiation therapy in the past. * Patients with bone related diseases Dataset of defect acetabula used for reconstruction: • Patients who received radiation therapy in the past.

Trainings dataset for statistical shape model: * Patients where a bilateral CT of the hip was performed with unilateral pathologies. * We aim to include an equal amount of scans from each gender and varying ages. Dataset of defect acetabula used for reconstruction: * Patients who received a CT scan of the hip after removal of a primary/revision implant (e.g. patients where debridement was performed due to infection.) * Patients where the defect can be classified as a Paprosky 3a or 3b defect.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (1)

University Hospitals of Leuven

Pellenberg, Vlaams-Brabant, Belgium

Location

MeSH Terms

Conditions

Osteoarthritis, Hip; Hip Injuries

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 16, 2020
• First Posted: November 20, 2020
• Study Start: August 31, 2018
• Primary Completion: May 11, 2023
• Study Completion: May 11, 2023
• Last Updated: July 3, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)