Cardiac Performance in Mechanically Ventilated COVID-19 Patients

NCT04628195 | Completed

• 1 other identifier: 200422002
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Although COVID-19 affects primarily the respiratory system, several studies have shown evidence of cardiovascular alterations. Increased troponin levels were observed in a significant proportion of patients and this alteration was associated with higher mortality. In addition, case reports of cardiogenic shock or fulminant myocarditis have been communicated. Likewise, pulmonary embolism (PE), right ventricle dilation, and acute cor pulmonale (ACP) have also been described. Therefore, investigating cardiac function in COVID-19 is highly relevant, particularly in critically ill patients who are usually under sedation and mechanical ventilation, which may further impair cardiovascular function. Thus the objective is to determine the prevalence of left ventricle dysfunction and acute cor pulmonale, and its association with respiratory mechanics, in 100 consecutive critically ill COVID-19 patients, who were assessed with critical care echocardiography (CCE) within the first 24 hours of mechanical ventilation.

Conditions

Covid19; Acute Cor Pulmonale; Cardiac Failure

Keywords

Critical Care Echocardiography; Cardiac Function; Acute Cor Pulmonale; COVID-19; Mechanical Ventilation; SARS-CoV-2

Outcome Measures

Primary Outcomes (2)

• Percentage of patients with left ventricle dysfunction (hypokinetic)

  Hypokinetic left ventricle function (left ventricle ejection fraction \<45%)

  3 month

• Percentage of patients with acute cor pulmonale

  Acute cor pulmonale was defined as a dilated right ventricle (right ventricle end-diastolic area/left ventricle end-diastolic area ratio \>0.6) associated with the presence of paradoxical septum motion

  3 month

Secondary Outcomes (3)

• Differences in respiratory system compliance between patients with and without acute cor pulmonale

  Within the first 24 hours of mechanical ventilation.

• Differences in partial arterial pressure of carbon dioxide (PCO2) between patients with and without acute cor pulmonale

  Within the first 24 hours of mechanical ventilation.

• Differences in PaO2/FiO2 ratio between patients with and without acute cor pulmonale

  Within the first 24 hours of mechanical ventilation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with severe SARS-CoV-2 pneumonia, defined as respiratory failure requiring invasive mechanical ventilation.

You may qualify if:

• Covid-19 confirmed by a positive polymerase chain reaction test
• Mechanical ventilation

You may not qualify if:

• Up to 24 hours on mechanical ventilation
• Severe valvulopathy
• Poor ultrasound window
• Do-not-resuscitate status

Sponsors & Collaborators

• Pontificia Universidad Catolica de Chile: lead
• Clinica Alemana de Santiago: collaborator
• Hospital Barros Luco Trudeau: collaborator
• University of Chile: collaborator

Study Sites (1)

Pontificia Universidad Católica de Chile

Santiago, Santiago Metropolitan, 7550028, Chile

Location

Related Publications (20)

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MeSH Terms

Conditions

COVID-19; Heart Failure

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D. Intensivist

Study Record Dates

• First Submitted: November 10, 2020
• First Posted: November 13, 2020
• Study Start: April 1, 2020
• Primary Completion: June 30, 2020
• Study Completion: August 1, 2020
• Last Updated: November 13, 2020

Record last verified: 2020-11

Locations

CL (1)