Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

NCT04625478 | Completed

• 1 other identifier: 229
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI. The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Conditions

Staphylococcus; Bone and Joint Infection

Keywords

Bone and Joint Infection; Staphylococcus; intracellulare

Outcome Measures

Primary Outcomes (2)

• detection of intracellular staphylococci

  to explore if intracellular staphylococci can be observed on samples of patient having an osteo-articular infection with staphylococci

  2 months

• rate of localisation of intracellular staphylococci

  to explore where in what type of celles they can be observed on samples of patient having an osteo-articular infection with staphylococci

  2 months

Study Arms (1)

Patients having had an osteo-articular infection with Stahylococcus

Patients having had an osteo-articular infection with Stahylococcus managed at the Croix Rousse hospital

Other: Patients having had an osteo-articular infection with Stahylococcus

Interventions

Patients having had an osteo-articular infection with Stahylococcus OTHER

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Patients having had an osteo-articular infection with Stahylococcus

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients having had an osteo-articular infection with Staphylococci managed at the Croix-Rousse Hospital

You may qualify if:

• patients having had an osteo-articular infection with Staphylococci

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hospices Civils de Lyon

Lyon, 69004, France

Location

Related Links

• Related Info

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 6, 2020
• First Posted: November 12, 2020
• Study Start: December 1, 2020
• Primary Completion: September 20, 2021
• Study Completion: December 20, 2021
• Last Updated: December 19, 2025

Record last verified: 2025-12

Locations

FR (1)