The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

NCT04622384 | Completed

• 1 other identifier: 1-10-72-40-20(3)
• Study Type: observational
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT). Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.

Conditions

Acute Kidney Injury; Acute Kidney Failure Stage 3

Keywords

Ultrasound; Renal Replacement Therapy; Dialysis; Renal Doppler Ultrasound

Outcome Measures

Primary Outcomes (1)

• Dialysis weaning

  If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days.

  7 days

Secondary Outcomes (6)

• Renal Doppler arterial Resistive Index (RI)

  Measured at the beginning of weaning and after 6 hours.

• Renal Doppler Renal Venous Stasis Index (RVSI)

  Measured at the beginning of weaning and after 6 hours.

• Renal Doppler Venous Impedance Index (VII)

  Measured at the beginning of weaning and after 6 hours.

• Portal vein Doppler Pulsatility Fraction PF)

  Measured at the beginning of weaning and after 6 hours.

• Urine Output

  4 days

Study Arms (1)

ICU patients

Patients who are treated with dialysis as CRRT and planned to undergo dialysis weaning.

Other: Dialysis weaning

Interventions

Dialysis weaning OTHER

Dialysis weaning as planned by the attending ICU-physician.

ICU patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the ICU, Aarhus University Hospital who are treated with dialysis as CRRT and planned to undergo dialysis weaning as determined their attending ICU physician.

You may qualify if:

• All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning

You may not qualify if:

• Insufficient ultrasonographic imaging of the kidneys
• Known morphological kidney disease
• Previous need of chronic RRT
• Prior participation in the study
• Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device

Sponsors & Collaborators

• Johan Fridolf Hermansen: lead

Study Sites (1)

Aarhus University Hospital, Department of Anaesthesiology

Aarhus, 8200, Denmark

Location

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Peter Juhl-Olsen, MD, PhD

  Aarhus University Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 26, 2020
• First Posted: November 10, 2020
• Study Start: January 1, 2021
• Primary Completion: March 1, 2023
• Study Completion: March 1, 2023
• Last Updated: March 21, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)