Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

NCT04620941 | Completed DMC

• 1 other identifier: 27/12/2019-19/XI
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Conditions

Ventilator-associated Pneumonia (VAP)

Keywords

Ventilator-associated pneumonia; reticulocyte/hemoglobin ratio; neutrophil/lymphocyte ratio

Outcome Measures

Primary Outcomes (1)

• Early inflammation markers for VAP

  To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.

  7 days

Secondary Outcomes (1)

• morbidity and mortality

  7 days

Study Arms (1)

ventilator-associated pneumonia

Ret-He values will be studied on the day (1st day), 4th and 7th days of VID diagnosis in patients receiving mechanical ventilation support in the intensive care unit. The hemogram, CRP, and NLR values that are routinely studied in the intensive care unit will be recorded. In addition, in case of infection, the routinely studied procalcitonin value will also be recorded. The patient's age, gender, APACHE II, SOFA scores will be recorded; respiratory system examination, fever, the mental status evaluation will be done daily.

Diagnostic Test: reticulocyte/hemoglobin (Ret-He) ratio

Interventions

reticulocyte/hemoglobin (Ret-He) ratio DIAGNOSTIC_TEST

Ret-He values will be studied on the day (1st day), 4th and 7th days of the diagnosis of ventilator-associated pneumonia in patients hospitalized in the intensive care unit.

ventilator-associated pneumonia

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit

You may qualify if:

• Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit

You may not qualify if:

• Pulmonary or extrapulmonary infection before mechanical ventilation,
• severe immunosuppression,
• bleeding in the gastrointestinal system,
• using corticosteroids,
• neoplastic disease history

Sponsors & Collaborators

• Muğla Sıtkı Koçman University: lead

Study Sites (1)

Mugla Sitki Kocman Universty

Muğla, Kötekli, 48000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated

Interventions

Reticulocyte Count

Condition Hierarchy (Ancestors)

Healthcare-Associated Pneumonia; Cross Infection; Infections; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Erythrocyte Count; Blood Cell Count; Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• turhan togan

  Mugla Sitki Kocman Universty Department of Infection Disease

  STUDY CHAIR

• Canan Gursoy

  Mugla Sitki Kocma University Department of Intensive Care

  STUDY CHAIR

• Semra Demirbilek

  Mugla Sitki Kocman Universty Department of Anesthesia

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Muğla Sıtkı Koçman University Department of Anesthesiology Specialist

Study Record Dates

• First Submitted: November 3, 2020
• First Posted: November 9, 2020
• Study Start: February 21, 2022
• Primary Completion: September 21, 2023
• Study Completion: December 21, 2023
• Last Updated: November 6, 2024

Record last verified: 2024-11

Locations

TU (1)