A Multi-center, Retrospective Analysis of Clinical Character, Outcome and Prognosis of Lymphoepithelioma-like Carcinoma

NCT04614818 | Unknown DMC

• 1 other identifier: B2020-289-01
• Study Type: observational
• Target: 700
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators retrospective collect the clinical data of patients diagnosed with lymphoepithelioma-like carcinoma, including primary site, gender, age, smoking history, tumor stage, time of initial treatment, EBV-DNA copy number, first-line treatment and survival status.

Conditions

Lymphoepithelioma-Like Carcinoma; Lymphoepithelioma-Like Carcinoma of Thymus; Lung Cancer

Outcome Measures

Primary Outcomes (1)

• Progression-free survival

  The length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse.

  From date of diagnosis until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 12 months.

Secondary Outcomes (1)

• Overall survival

  From date of diagnosis until the date of death from any cause, whichever came first, assessed up to 24 months.

Study Arms (9)

pulmonary lymphoepithelioma-like carcinoma

The primary site of lymphoepithelioma-like carcinoma locates in the lungs.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of thymus

The primary site of lymphoepithelioma-like carcinoma locates in the thymus.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of salivary glands

The primary site of lymphoepithelioma-like carcinoma locates in the parotid gland or submandibular gland.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of stomach

The primary site of lymphoepithelioma-like carcinoma locates in the stomach.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of esophagus

The primary site of lymphoepithelioma-like carcinoma locates in the esophagus.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of liver

The primary site of lymphoepithelioma-like carcinoma locates in the liver.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of ovaries

The primary site of lymphoepithelioma-like carcinoma locates in the ovaries.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of cervix

The primary site of lymphoepithelioma-like carcinoma locates in the cervix.

Other: Non-intervention research

lymphoepithelioma-like carcinoma of tonsil

The primary site of lymphoepithelioma-like carcinoma locates in the tonsil.

Other: Non-intervention research

Interventions

Non-intervention research OTHER

Non-intervention research

lymphoepithelioma-like carcinoma of cervix; lymphoepithelioma-like carcinoma of esophagus; lymphoepithelioma-like carcinoma of liver; lymphoepithelioma-like carcinoma of ovaries; lymphoepithelioma-like carcinoma of salivary glands; lymphoepithelioma-like carcinoma of stomach; lymphoepithelioma-like carcinoma of thymus; lymphoepithelioma-like carcinoma of tonsil; pulmonary lymphoepithelioma-like carcinoma

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with confirmed diagnosis of lymphoepithelioma-like carcinoma of any primary site, including lung, salivary glands, thymus, tonsil, liver, stomach, esophagus, ovary, cervix et al.

You may qualify if:

• \. Lymphoepithelioma-like carcinoma confirmed by histopathology;
• \. The primary lesion does not involve the nasopharynx;
• \. Complete data for patient's character, laboratory and imaging test, treatment and follow-up are available.

You may not qualify if:

• \. Concomitant with other tumor components at the time of diagnosis;
• \. Have a history of any other malignant tumors;
• \. Lack of complete data

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

Sun yat-sen University Cancer Center

Guangzhou, Guangdong, 510060, China

RECRUITING

Related Publications (5)

• Wu Q, Wang W, Zhou P, Fu Y, Zhang Y, Shao YW, Jiang L. Primary pulmonary lymphoepithelioma-like carcinoma is characterized by high PD-L1 expression, but low tumor mutation burden. Pathol Res Pract. 2020 Aug;216(8):153043. doi: 10.1016/j.prp.2020.153043. Epub 2020 Jun 2.

  PMID: 32703503 BACKGROUND

• Fang W, Hong S, Chen N, He X, Zhan J, Qin T, Zhou T, Hu Z, Ma Y, Zhao Y, Tian Y, Yang Y, Xue C, Tang Y, Huang Y, Zhao H, Zhang L. PD-L1 is remarkably over-expressed in EBV-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival. Oncotarget. 2015 Oct 20;6(32):33019-32. doi: 10.18632/oncotarget.5028.

  PMID: 26361045 BACKGROUND

• He J, Shen J, Pan H, Huang J, Liang W, He J. Pulmonary lymphoepithelioma-like carcinoma: a Surveillance, Epidemiology, and End Results database analysis. J Thorac Dis. 2015 Dec;7(12):2330-8. doi: 10.3978/j.issn.2072-1439.2015.12.62.

  PMID: 26793355 BACKGROUND

• Abouelfad DM, Yassen NN, Amin HAA, Shabana ME. Lymphoepithelioma-Like Carcinoma of the Breast Mimicking Granulomatous Mastitis- Case Report and Review of the Literature. Asian Pac J Cancer Prev. 2017 Jul 27;18(7):1737-1741. doi: 10.22034/APJCP.2017.18.7.1737.

  PMID: 28749097 BACKGROUND

• Chen M, Chen Y, Fang X, Wang Z, Pu X, Liang C, Guo H, Li Q, Pan F, Hong H, Huang H, Li J, Lin T. Clinical features and treatment outcome of lymphoepithelioma-like carcinoma from multiple primary sites: a population-based, multicentre, real-world study. BMC Pulm Med. 2022 Sep 22;22(1):360. doi: 10.1186/s12890-022-02097-6.

  PMID: 36138362 DERIVED

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 26, 2020
• First Posted: November 4, 2020
• Study Start: January 1, 2008
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2021
• Last Updated: November 4, 2020

Record last verified: 2020-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)