To Check Effectiveness of Medistus Antivirus Lozenges for Cough

NCT04612829 | Completed Phase 2 DMC

• 1 other identifier: NUTRIN002
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

A thraot infection sometimes called pharyngitis can be either a bacterial or a viral infection leading to inflammation of the tissues of the throat that causes redness, pain and swelling of the walls and structure of the throat. The throat or Pharynx is the tube like structure that carries both food to the oesophagus and air to your wind pipe (called the larynx). Infective agents of the throat most often enters through the month or nose. Many of these infections are viral, other can be caused by bacteria such as Streptococcus Pyogenes, or Group A streptococcus. Symtoms of throat infections most commonly includes pain and a sensation of heat in the throat or Pharynx. Viral infections accounts for approx. 70% of all pharyngitis. Rhinovirus is the most common cause of viral infections. The other common causes of viral infections in descending order are corona virus, adeno virus, para influenza, and influenza virus. Viral infections are more common during the winter month with the exception of adeno viruses which occur year round. Viral Pharyngitis is spread through similar mechanism as other viral infections. Hand to mouth contact, contact with oral secretions, and sharing common utensils, all contributes to viral spread. Prevention of the spread of diseases is based on frequent hand washing, and clinical symptoms of different viruses are more prevalent during certain seasons. Coryza, conjectivitis, malease, or fatigue, hoarseness, and low grade fever such as the presence of viral phayngitis. Subjects with viral pharyngitis can also have atypical symptoms such as mouth breathing, nausea, abdominal pain, and diarrhoea. Medistus Antivirus is a medical device product with a noble impact. Kistosyn 100 extract contains polyphenols, and with the help of gum arabic, it forms a protective film over the mouth and throat mucus membranes. This protective Barrier lead to a physical (mechanical) barrier against viruses and bacteria which prevent their penetration into body cells, and their further propagation. Due to this physical effect, resistance development is not possible.

Conditions

Throat Infection; Pharyngitis; Sore Throat

Keywords

medistus; nutrin gmbh; throat infection; Pharyngitis; Antivirus

Outcome Measures

Primary Outcomes (4)

• To assess the cough episodes count

  data collection on visit 2 from the subject for improvement in cough count

  5 days

• Throat pain assessment

  on severity scale of 0-4

  5 days

• Redness of throat

  on severity scale of 0-4

  5 days

• Swelling assessment

  on severity scale of 0-4

  5 days

Study Arms (1)

Intervention- Medistus Antivirus Lozenges

EXPERIMENTAL

A blend of Kistosyn Extract with Gum Arabic 1 Lozenge after every 2 hours, 5 times a day. Mode of Administration: Oral Duration of Treatment: 5 days

Device: Medistus Antivirus Lozenges

Interventions

Medistus Antivirus Lozenges DEVICE

A blend of Kistosyn Extract with Gum Arabic

Intervention- Medistus Antivirus Lozenges

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient with mild to moderate acute Pharyngitis or sore throat or strep throat
• Voluntarily signed informed consent for participation in this clinical study
• Compliance by the patient seems guaranteed, and the patient seems to be able to understand and complete the patient diary.

You may not qualify if:

• Severe respiratory tract infection (pneumonia, bronchitis or laryngitis)
• Oro-pharyngeal paresthesia or mycosis
• Severely traumatised and/or very severe oromucosal inflammation
• Tonsillopharyngectomy
• Peritonsillar abscess
• Long term use (≥ 3 times per week within the last month or regular intake within the last 3 months before randomisation) of antiinflammatory drugs- Any long-acting or slow release analgesic intake including NonSteroidal Anti-Inflammatory Drugs(NSAIDs)within 24 hours before randomisation (e.g. piroxicam or naproxen)
• Any anti-inflammatory drugs intake by systemic route within 12 hours before assigning
• Any paracetamol intake within 6 hours before randomisation
• Any cold medication (decongestant, antihistamine, expectorant, antitussive) within 6 hours before randomisation
• Any topical throat medication intake containing or not a local oral anaesthetic such as lozenge, spray, mouth rinse within 4 hours before recruitment
• Heavy smokers (\>20 cigarettes/day)

Sponsors & Collaborators

• Nutrin GmbH: lead

Study Sites (1)

Arogyam Superspeciality Hospital

Nagpur, Maharashtra, 440025, India

Location

MeSH Terms

Conditions

Pharyngitis

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Pharyngeal Diseases; Stomatognathic Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases

Study Officials

• Puneet Mittal

  Mittal Global Clinical Trial Services

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2020
• First Posted: November 3, 2020
• Study Start: August 23, 2017
• Primary Completion: October 15, 2017
• Study Completion: October 15, 2017
• Last Updated: November 3, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

IN (1)