NCT04612036

Brief Summary

The objective of this study is to determine and compare the in vivo kinematics and vibroarthrography (VAG) signals for subjects implanted with Journey II Bi-Cruciate Stabilized (BCS), CR (Cruciate Retaining), and Bi-Cruciate Retaining (XR) TKAs.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Oct 2020

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 22, 2020

Completed
5 days until next milestone

First Submitted

Initial submission to the registry

October 27, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

November 2, 2020

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 16, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 16, 2022

Completed
1.5 years until next milestone

Results Posted

Study results publicly available

November 29, 2023

Completed
Last Updated

November 29, 2023

Status Verified

February 1, 2023

Enrollment Period

1.6 years

First QC Date

October 27, 2020

Results QC Date

May 17, 2022

Last Update Submit

February 20, 2023

Conditions

Keywords

Total Knee Arthroplasty

Outcome Measures

Primary Outcomes (4)

  • Medial AP Translations, in mm

    Anterior Posterior (AP) translations, in mm, of medial femoral condyle during Deep Knee Bend Activity. Values are based on the participants range of motion throughout their DKB activity. A positive number indicated anterior sliding from full extension to maximum flexion, and a negative number indicated posterior rollback from full extension to maximum flexion.

    At least 6 months postoperative

  • Lateral AP Translations, in mm

    Anterior Posterior (AP) translations, in mm, of lateral femoral condyle during Deep Knee Bend Activity. Values are based on the participants range of motion throughout their DKB activity. A positive number indicated anterior sliding from full extension to maximum flexion, and a negative number indicated posterior rollback from full extension to maximum flexion.

    At least 6 months postoperative

  • Maximum Flexion, in Degrees

    Maximum weight-bearing flexion, in degrees, during Deep Knee Bend Activity. Maximum flexion indicated how far a participant can bend their knee during a DKB. A larger number indicates greater flexion, i.e. more bending.

    At least 6 months postoperative

  • Axial Rotation, in Degrees

    Axial Rotation, in degrees, during Deep Knee Bend Activity. Values are based on the participants range of motion throughout their squat activity. A positive number indicates external femorotibial axial rotation from full extension to maximum flexion, and a negative number indicates internal femorotibial axial rotation from full extension to maximum flexion.

    At least 6 months postoperative

Study Arms (3)

Journey II Bi-Cruciate Stabilized

Subjects who have received a Journey II Total Knee Arthroplasty with both the ACL and PCL resected

Device: Journey II Bi-Cruciate Stabilized TKA

Journey II Cruciate Retaining

Subjects who have received a Journey II Total Knee Arthroplasty with only the ACL resected (therefore PCL retained)

Device: Journey II Cruciate Retaining TKA

Journey II Bi-Cruciate Retaining

Subjects who have received a Journey II Total Knee Arthroplasty with both the ACL and PCL retained

Device: Journey II Bi-Cruciate Retaining TKA

Interventions

Total Knee Arthroplasty System

Journey II Bi-Cruciate Stabilized

Total Knee Arthroplasty System

Journey II Cruciate Retaining

Total Knee Arthroplasty System

Journey II Bi-Cruciate Retaining

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with Journey II Bi-Cruciate Stabilized (BCS), CR (Cruciate Retaining), and Bi-Cruciate Retaining (XR) TKAs

You may qualify if:

  • Patients in the age range of 18 years to 85 years (both inclusive)
  • Patients who have a BMI less than 35
  • Patients who do not have previous surgery on the implanted knee that might restrict their movement
  • Patient who are at least 6 months post-operative
  • Patients who do not experience any pain or other post-operative complications
  • Patients who have a stable TKA and can perform a deep knee bend activity
  • Patients who are willing to participate in this study and are willing to sign appropriate HIPAA and informed consent forms
  • Subjects will have a Journey II, either the BCS or XR, knee system

You may not qualify if:

  • Pregnant, potentially pregnant, or lactating females. To satisfy radiation protocol, each female subject will be asked if she is pregnant, or possibly could be pregnant. A pregnant person will not be allowed to participate in the study.
  • Patients who have currently enrolled in a fluoroscopic study within the past year.
  • Patients currently involved in any personal injury litigation, medical/legal or workman's compensation claims.
  • Patients with known drug or alcohol abuse histories or psychological disorders that could affect ability to complete all aspects of the study.
  • Patients with neurological or musculoskeletal disorders that might adversely affect weight-bearing motion ability
  • Subjects who are unable to perform a deep knee bend.
  • Subjects who are unwilling to sign Informed Consent/ HIPAA documents.
  • Subjects without the required type of knee implant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Tennessee

Knoxville, Tennessee, 37996, United States

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Results Point of Contact

Title
Michael LaCour
Organization
University of Tennessee

Study Officials

  • Michael LaCour, PhD

    The University of Tennessee

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 27, 2020

First Posted

November 2, 2020

Study Start

October 22, 2020

Primary Completion

May 16, 2022

Study Completion

May 16, 2022

Last Updated

November 29, 2023

Results First Posted

November 29, 2023

Record last verified: 2023-02

Data Sharing

IPD Sharing
Will not share

Researchers would like to retain this study data in our secure database so as to continue to add relevant, current data to our digital collection to help us work with manufacturers in the future to create better implants that last longer and will not require revision surgery. Participants will be asked if their study data may remain a part of the University of Tennessee's Center for Musculoskeletal Research data collection for use in future studies in the IC. Identifiers are automatically removed from the database upon entry into the secure server. Data shared with sponsors is de-identified.

Locations