OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment

NCT04611984 | Completed

• 1 other identifier: 04.03.2013.38
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.

Conditions

Tooth Movement

Keywords

Tooth movement; Piezocision; Gingival crevicular fluid; Osteocalcin

Outcome Measures

Primary Outcomes (2)

• Gingival crevicular fluid osteocalcin level (ng/ml)

  Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of osteocalcin was determined by using ELISA

  28 days after canine distalization

• Gingival crevicular fluid cross-linked C-terminal telopeptides of type I level (ng/ml)

  Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of cross-linked C-terminal telopeptides of type I collagen was determined by using ELISA.

  28 days after canine distalization

Secondary Outcomes (2)

• The amount of canine movement (mm)

  Baseline (day 0) before canine distalization and, 14 and 28 days after canine distalization

• Retraction rate (mm/day) of canine movement

  14 and 28 days after canine distalization

Study Arms (2)

Piezocision

EXPERIMENTAL

Piezocision was performed on the mesial and distal side of the maxillary right canine tooth which was served as the piezocision group. Then canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Procedure: Piezocision

Control

ACTIVE COMPARATOR

Maxillary left canine served as the control group and canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Procedure: Control

Interventions

Piezocision PROCEDURE

Piezocisions were performed on the mesial and distal sides of the right maxillary canines. Then canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Piezocision

Control PROCEDURE

The mesial and distal sides of the left maxillary canines served as controls and canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Control

Eligibility Criteria

• Age: 13 Years - 20 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Class I, Class II or Class III malocclusion,
• Proclined incisors requiring extraction of the maxillary first premolars with subsequent retraction of the maxillary canines
• No previous orthodontic treatment
• Good oral hygiene and periodontal health (plaque and gingival indices less or equal 1, probing depth less or equal 3 mm, no radiographic bone loss).

You may not qualify if:

• having systemic diseases that could affect bone and tooth movement
• smoking

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Marmara University Faculty of Dentistry

Istanbul, 34854, Turkey (Türkiye)

Location

Related Publications (3)

• Dibart S, Surmenian J, Sebaoun JD, Montesani L. Rapid treatment of Class II malocclusion with piezocision: two case reports. Int J Periodontics Restorative Dent. 2010 Oct;30(5):487-93.

  PMID: 20814602 BACKGROUND

• Alfaqeeh SA, Anil S. Osteocalcin and N-telopeptides of type I collagen marker levels in gingival crevicular fluid during different stages of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):e553-9. doi: 10.1016/j.ajodo.2011.03.005.

  PMID: 21640867 BACKGROUND

• Raj SC, Praharaj K, Barik AK, Patnaik K, Mahapatra A, Mohanty D, Katti N, Mishra D, Panda SM. Retraction With and Without Piezocision-Facilitated Orthodontics: A Randomized Controlled Trial. Int J Periodontics Restorative Dent. 2020 Jan/Feb;40(1):e19-e26. doi: 10.11607/prd.3968.

  PMID: 31815981 BACKGROUND

Study Officials

• Hatice Selin Yıldırım, Dr.

  Marmara University, Faculty of Dentistry, Department of Peridontology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The investigators performing the clinical and surgical procedures, and patients were not blinded. Data assessment was performed by a blinded researcher. Gingival crevicular fluid samples were collected and numbered by another blinded researcher.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 20, 2020
• First Posted: November 2, 2020
• Study Start: March 1, 2013
• Primary Completion: August 1, 2014
• Study Completion: August 1, 2014
• Last Updated: November 2, 2020

Record last verified: 2020-10

Locations

TU (1)