Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor in Increasing Pregnancy Rate in ICSI
Intra Uterine Injection of Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor at Ovum Pick up Day Significantly Increase Implantation Rate and Pregnancy Rate in Intra Cytoplasmic Sperm Injection
1 other identifier
interventional
200
0 countries
N/A
Brief Summary
Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a secondary outcome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Oct 2020
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 23, 2020
CompletedFirst Posted
Study publicly available on registry
October 28, 2020
CompletedStudy Start
First participant enrolled
October 30, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 10, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
January 10, 2021
CompletedOctober 28, 2020
October 1, 2020
2 months
October 23, 2020
October 23, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
clinical pregnancy rate
Clinical pregnancy was evaluated by high HCG levels
after 14 days from positive pregnancy test
Secondary Outcomes (1)
Gestational sac imaging
6 weeks of pregnancy
Study Arms (2)
Group 1
EXPERIMENTALGranulocyte Colony Stimulated Factor was intrauterine injected once at ovum pick up day
Group 2
ACTIVE COMPARATOR500 IU Human Chorionic Gonadotropins was injected intrauterine once at ovum pick up day
Interventions
GCSF was intrauterine injected once at ovum pick up day
500 IU of HCG was injected intrauterine once at ovum pick up day
Eligibility Criteria
You may qualify if:
- Females suffering from recurrent implantation failure and undergoing ICSI
You may not qualify if:
- presence of comorbidity as diabetes, hypertension, heart diseases, or endocrine disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Elsayed Eldesouky
Assistant professor of obstetrics and gynecology faculty of medicine Alazhar university Cairo
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant professor of obstetrics and gynecology faculty of medicine Alazhar university Cairo
Study Record Dates
First Submitted
October 23, 2020
First Posted
October 28, 2020
Study Start
October 30, 2020
Primary Completion
January 10, 2021
Study Completion
January 10, 2021
Last Updated
October 28, 2020
Record last verified: 2020-10