Urine pH and Urinary Tract Infection
PHURINE
Consequences of UTI on Urine pH
1 other identifier
observational
50
1 country
1
Brief Summary
Urinary tract infections (UTI) affect the urine pH and may lead to salt precipitation such as struvite. Bacteria with urease activity are known to alkalinise urine, but not much is known on how pH is changing over time during UTI. This study aims at following urine pH progression at the time of diagnosis of UTI and during the treatment phase. Description of the change in urine pH over time will help understanding the risk of struvite formation and potential timing of intervention.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2020
CompletedFirst Submitted
Initial submission to the registry
October 13, 2020
CompletedFirst Posted
Study publicly available on registry
October 22, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 13, 2021
CompletedOctober 22, 2020
October 1, 2020
5 months
October 13, 2020
October 19, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Urine pH
Urine pH is monitored by the patient every morning during the treatment phase and 7 days after the end of treatment
21 days
Study Arms (2)
Cystitis
Patients with lower UTI will be included in this group
Pyelonephritis
Patients with higher UTI will be included in this group
Eligibility Criteria
Patient consulting the primary care unit of the medical outpatient clinic UniSanté in Lausanne will be asked to participate.
You may qualify if:
- Symptoms of dysuria, pollakiuria, no fever AND
- urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml)
- Group 2. Pyelonephritis
- Unilateral flank pain, pollakiuria, dysuria, fever (\>38.5°C) AND
- urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml)
You may not qualify if:
- known urinary tract anatomic abnormalities
- Presence of a urine catheter
- Sepsis - septic shock
- Patient taking drug interfering with urine pH (diuretics, citrate, acetazolamide, topiramate,...)
- Patients with UTI diagnosed in the preceding month
- Patients having received antibiotics during the preceding month
- Male patient with a diagnosis of prostatitis
- Presence of infected kidney cyst
- Patient with diabetes
- Pregnant female
- Patient with obstructive pyelonephritis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UniSanté
Lausanne, Canton of Vaud, 1011, Switzerland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Olivier Bonny, MD-PhD
CHUV-Lausanne
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
October 13, 2020
First Posted
October 22, 2020
Study Start
August 1, 2020
Primary Completion
December 31, 2020
Study Completion
December 13, 2021
Last Updated
October 22, 2020
Record last verified: 2020-10
Data Sharing
- IPD Sharing
- Will not share